Sitapep gm 1/50/500 mg Tablet

Composition of Sitapep gm 1/50/500 mg Tablet

Sitapep gm 1/50/500 mg Tablet contains Glimepiride 1 mg + Sitagliptin 50 mg + Metformin 500 mg (as Metformin Hydrochloride). It belongs to the Biguanide + Sulfonylurea + DPP-4 inhibitor class of medicines.

Uses of Sitapep gm 1/50/500 mg Tablet

• Type 2 diabetes mellitus: to help control blood sugar in adults when diet and exercise alone are not enough
• as prescribed.

Key benefits

• Helps lower fasting and post-meal blood sugar
• Improves insulin secretion and sensitivity
• Better HbA1c control with combination therapy
• May reduce risk of diabetes-related complications with good control

How Sitapep gm 1/50/500 mg Tablet works

Metformin decreases glucose production in the liver and improves insulin sensitivity. Glimepiride (a sulfonylurea) increases insulin release from the pancreas. Sitagliptin (a DPP-4 inhibitor) increases incretin levels, improving insulin release and reducing glucagon in a glucose-dependent manner.

How to take Sitapep gm 1/50/500 mg Tablet

Take by mouth exactly as prescribed. Usually taken with food (preferably with/after meals) to reduce stomach upset; swallow whole with water. Do not skip meals; monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It may cause low blood sugar, particularly if you also take other diabetes medicines. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Sitapep gm 1/50/500 mg Tablet

Most side effects of Sitapep gm 1/50/500 mg are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• headache
• dizziness
• flatulence

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Sitapep gm 1/50/500 mg Tablet

Warnings and precautions

Risk of hypoglycaemia (higher if meals are missed, with alcohol, or with other antidiabetics); metformin may rarely cause lactic acidosis—seek urgent care for rapid breathing, severe weakness, muscle pain, unusual sleepiness. Use caution in kidney or liver disease; dose adjustment/avoidance may be needed. Withhold metformin around iodinated contrast procedures and major surgery as advised. Not for type 1 diabetes or diabetic ketoacidosis. Elderly and malnourished patients are at higher hypoglycaemia risk.

Do not take Sitapep gm 1/50/500 mg if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol, insulin/other antidiabetics (additive hypoglycaemia), corticosteroids (raise glucose), diuretics and sympathomimetics (raise glucose), ACE inhibitors (may enhance glucose-lowering), fluoroquinolones (glycaemic disturbances), beta-blockers (mask hypoglycaemia), iodinated contrast media (metformin—lactic acidosis risk), cationic drugs affecting renal excretion (e.g., cimetidine)

How to store Sitapep gm 1/50/500 mg Tablet

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Expert advice for Sitapep gm 1/50/500 mg Tablet

Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

MEXICAN WAVE PHARMA

Therapeutic class:

Antidiabetic

Drug class:

Biguanide + Sulfonylurea + DPP-4 inhibitor