Prescription requiredAntidiabetic

Zukanorm M 500 Tablet — Side Effects & Warnings

Known side effects of Zukanorm M 500 Tablet include Nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, flatulence, headache. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated August 2026

Common Side Effects

Nausea
vomiting
diarrhoea
abdominal pain
loss of appetite
metallic taste
flatulence
headache

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Risk of lactic acidosis (rare but serious) especially with kidney impairment, dehydration, severe infection, shock, heavy alcohol use, or heart/liver failure—seek urgent care for rapid breathing, severe weakness, abdominal pain, or drowsiness. Dose adjustment/avoid in reduced kidney function; periodic eGFR monitoring needed. Stop temporarily before iodinated contrast imaging and major surgery as advised. Long-term use may cause vitamin B12 deficiency; monitor if anaemia/neuropathy. Not for type 1 diabetes or diabetic ketoacidosis.

Drug Interactions

Zukanorm M 500 Tablet may interact with the following:

Alcohol (increases lactic acidosis risk)
iodinated contrast media
carbonic anhydrase inhibitors (e.g.
topiramate
acetazolamide)
cimetidine
diuretics
corticosteroids
thyroid hormones
sympathomimetics
antipsychotics (e.g.
olanzapine)
other antidiabetic medicines/insulin (may increase hypoglycaemia risk when combined)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor

Alcohol Interaction

Avoid

Habit Forming

Storage

Store below 25°C in a dry place, protected from moisture and light. Keep out of reach of children.

Zukanorm M 500 Tablet — Safety Summary

Composition: Metformin (500mg) + Vildagliptin (50mg)
Prescription: Required (Rx)
Pregnancy: Consult doctor
Alcohol: Avoid
Habit forming: No

Zukanorm M 500 Tablet — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.