Drug | Tablet

Prevention and treatment of blood clots (thromboembolism) such as deep vein thrombosis (DVT), pulmonary embolism (PE); prevention of stroke/systemic embolism in atrial fibrillation; prevention of clotting in patients with mechanical heart valves; secondary prevention after myocardial infarction where anticoagulation is indicated

Acenocoumarol is a vitamin K antagonist anticoagulant. It inhibits vitamin K–dependent synthesis of clotting factors II, VII, IX and X in the liver, thereby reducing the blood’s ability to form clots. Its effect is monitored using INR and dose is adjusted accordingly.

Take exactly as prescribed by your doctor; dose is individualized based on INR. Usually taken once daily at the same time each day, with or without food. Do not stop, skip, or double doses; if a dose is missed, take it the same day as soon as remembered (do not double the next day). Regular INR testing is essential.

Bleeding (nosebleeds, gum bleeding, easy bruising), prolonged bleeding from cuts, blood in urine, black/tarry stools, nausea, vomiting, diarrhea, abdominal pain, rash, hair loss, dizziness

Risk of serious/life-threatening bleeding—seek urgent care for severe headache, weakness, coughing/vomiting blood, black stools, heavy menstrual bleeding, or any unusual bleeding. Requires regular INR monitoring and dose adjustments. Inform doctor before any surgery/dental procedure; may need temporary stoppage/bridging. Maintain consistent dietary vitamin K intake (avoid sudden changes in green leafy vegetables); avoid OTC NSAIDs/aspirin unless advised. Use caution in liver/kidney disease, uncontrolled hypertension, history of bleeding, peptic ulcer, alcoholism, elderly. Contraindicated in active bleeding, severe bleeding disorders, recent major surgery with high bleeding risk, and known hypersensitivity.

Aspirin and other antiplatelets (clopidogrel), NSAIDs (ibuprofen, diclofenac), other anticoagulants (heparin, enoxaparin, dabigatran/rivaroxaban/apixaban), antibiotics (metronidazole, co-trimoxazole, macrolides, fluoroquinolones), antifungals (fluconazole, ketoconazole), amiodarone, statins (some), anticonvulsants (phenytoin, carbamazepine), rifampicin, thyroid hormones, corticosteroids, SSRIs/SNRIs, herbal products (ginkgo, garlic, ginseng, St John’s wort), vitamin K supplements

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Acitrom 1 Tablet, Sintrom 2 Tablet, Acenocoumarol 2 mg Tablet (generic), Acitrom 3 Tablet, Acitrom 4 Tablet