May cause sedation, impaired alertness and falls—avoid driving or operating machinery. Risk of dependence, misuse and withdrawal; use the lowest effective dose for the shortest duration. Do not stop abruptly (may cause withdrawal symptoms, rebound anxiety, seizures). Use caution in elderly, depression/suicidal thoughts, history of substance abuse, liver disease, kidney disease, respiratory disease (COPD/sleep apnea). Concomitant use with opioids or other CNS depressants can cause profound sedation, respiratory depression, coma or death.
