Carvedilol 12.5 mg + Ivabradine 5 mg (tablet)
Tablet
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Before you take it
Consult doctor (generally not recommended unless clearly needed)
Use with caution (may increase dizziness and low blood pressure)
Monograph
Tablet
Chronic heart failure (stable) and chronic stable angina in patients where heart rate control is needed; used to reduce heart rate, improve symptoms and exercise tolerance, and reduce risk of worsening heart failure as prescribed.
Carvedilol is a non-selective beta-blocker with alpha-1 blocking action that slows the heart rate and lowers blood pressure, reducing cardiac workload. Ivabradine selectively inhibits the If current in the sinoatrial node, lowering heart rate without reducing contractility. Together they improve heart efficiency and symptom control in selected patients.
Take by mouth exactly as prescribed. Usually taken twice daily with food (carvedilol is best taken with meals to reduce dizziness); swallow whole with water. Do not stop suddenly; dose is typically titrated based on heart rate and blood pressure.
Dizziness, fatigue, low blood pressure, slow heart rate (bradycardia), headache, nausea, visual brightness/photopsia, shortness of breath, swelling (edema)
Prescription-only. Can cause excessive slowing of heart rate, low blood pressure, worsening heart failure during initiation/titration, and dizziness/fainting—monitor BP and pulse. Not recommended in severe bradycardia, sick sinus syndrome/AV block without pacemaker, acute decompensated heart failure, severe hypotension, severe hepatic impairment, or cardiogenic shock. Use caution in asthma/COPD, diabetes (may mask hypoglycemia), peripheral vascular disease, thyroid disorders, and in elderly. Do not stop abruptly (risk of angina/arrhythmia). Seek urgent care for fainting, very slow pulse, severe breathlessness, or chest pain.
Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, telithromycin, ritonavir) and non-dihydropyridine calcium channel blockers (verapamil, diltiazem) increase ivabradine levels and bradycardia risk; other heart-rate-lowering drugs (digoxin, amiodarone, beta-blockers) increase bradycardia/AV block risk; antihypertensives and nitrates increase hypotension risk; CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John’s wort) may reduce ivabradine effect; insulin/oral antidiabetics—monitor glucose; clonidine—withdrawal interactions; NSAIDs may reduce antihypertensive effect.
Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.
Ivabradine 5 mg + Carvedilol 12.5 mg tablets (generic equivalents), CARVA-IVA 12.5/5 Tablet, Carva-Iva 12.5/5 Tablet, Ivacard CV 12.5/5 Tablet, Coralan CV 12.5/5 Tablet
At a glance
Good to know
Chronic heart failure (stable) and chronic stable angina in patients where heart rate control is needed; used to reduce heart rate, improve symptoms and exercise tolerance, and reduce risk of worsening heart failure as prescribed.
Dizziness, fatigue, low blood pressure, slow heart rate (bradycardia), headache, nausea, visual brightness/photopsia, shortness of breath, swelling (edema)
Carvedilol is a non-selective beta-blocker with alpha-1 blocking action that slows the heart rate and lowers blood pressure, reducing cardiac workload. Ivabradine selectively inhibits the If current in the sinoatrial node, lowering heart rate without reducing contractility. Together they improve heart efficiency and symptom control in selected patients.
Take by mouth exactly as prescribed. Usually taken twice daily with food (carvedilol is best taken with meals to reduce dizziness); swallow whole with water. Do not stop suddenly; dose is typically titrated based on heart rate and blood pressure.
Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.
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Brand
Serdia Pharmaceuticals India Pvt Ltd
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Manufacturer: SERDIA PHARMACEUTICALS`
Medical disclaimer: product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalised guidance. Sources: Manufacturer labeling, established medical literature (cardiology guidelines), standard drug references (e.g., Martindale/BNF), CDSCO/Indian prescribing information
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