Carivalan 12.5/5 Tablet

Carivalan 12.5/5 Tablet contains Carvedilol 12.5 mg + Ivabradine 5 mg (tablet). Prescription required.

Chronic heart failure (stable) and chronic stable angina in patients where heart rate control is needed; used to reduce heart rate, improve symptoms and exercise tolerance, and reduce risk of worsening heart failure as prescribed.

Carvedilol is a non-selective beta-blocker with alpha-1 blocking action that slows the heart rate and lowers blood pressure, reducing cardiac workload. Ivabradine selectively inhibits the If current in the sinoatrial node, lowering heart rate without reducing contractility. Together they improve heart efficiency and symptom control in selected patients.

Take by mouth exactly as prescribed. Usually taken twice daily with food (carvedilol is best taken with meals to reduce dizziness); swallow whole with water. Do not stop suddenly; dose is typically titrated based on heart rate and blood pressure.

Dizziness, fatigue, low blood pressure, slow heart rate (bradycardia), headache, nausea, visual brightness/photopsia, shortness of breath, swelling (edema)

Prescription-only. Can cause excessive slowing of heart rate, low blood pressure, worsening heart failure during initiation/titration, and dizziness/fainting—monitor BP and pulse. Not recommended in severe bradycardia, sick sinus syndrome/AV block without pacemaker, acute decompensated heart failure, severe hypotension, severe hepatic impairment, or cardiogenic shock. Use caution in asthma/COPD, diabetes (may mask hypoglycemia), peripheral vascular disease, thyroid disorders, and in elderly. Do not stop abruptly (risk of angina/arrhythmia). Seek urgent care for fainting, very slow pulse, severe breathlessness, or chest pain.

Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, telithromycin, ritonavir) and non-dihydropyridine calcium channel blockers (verapamil, diltiazem) increase ivabradine levels and bradycardia risk; other heart-rate-lowering drugs (digoxin, amiodarone, beta-blockers) increase bradycardia/AV block risk; antihypertensives and nitrates increase hypotension risk; CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John’s wort) may reduce ivabradine effect; insulin/oral antidiabetics—monitor glucose; clonidine—withdrawal interactions; NSAIDs may reduce antihypertensive effect.

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Ivabradine 5 mg + Carvedilol 12.5 mg tablets (generic equivalents), CARVA-IVA 12.5/5 Tablet, Carva-Iva 12.5/5 Tablet, Ivacard CV 12.5/5 Tablet, Coralan CV 12.5/5 Tablet