Drug | Tablet

Used to reduce heart rate in chronic stable angina (chest pain) and in chronic heart failure (with reduced ejection fraction) in eligible patients, as prescribed by a cardiologist.

Ivabradine selectively inhibits the If (funny) current in the sinoatrial node, slowing the heart rate without reducing cardiac contractility. Lower heart rate decreases myocardial oxygen demand and can improve symptoms in angina and outcomes in selected heart failure patients.

Take exactly as prescribed, usually twice daily with meals. Swallow tablet with water. Do not stop suddenly without medical advice; dose may be adjusted based on resting heart rate and tolerance.

Bradycardia, Visual brightness (phosphenes), Dizziness, Fatigue, Headache, Atrial fibrillation, Low blood pressure, Nausea

Not recommended in severe bradycardia, acute heart failure, cardiogenic shock, sick sinus syndrome, SA block, 3rd degree AV block (unless paced), severe hypotension, severe hepatic impairment, or in pregnancy. Monitor heart rate and rhythm; seek care for palpitations, fainting, or new/worsening breathlessness.

Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, erythromycin, HIV protease inhibitors), CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John"s wort), Verapamil, Diltiazem, Other heart-rate lowering drugs (beta-blockers, digoxin, amiodarone) increasing bradycardia risk, Grapefruit juice

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister.

Coralan 7.5 Tablet