Drug | Tablet

Type 2 diabetes mellitus (to control high blood sugar in adults), Used when diet and exercise alone or single therapy is insufficient

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and helps lower blood glucose. Metformin (a biguanide) reduces glucose production in the liver and improves insulin sensitivity. Together they improve fasting and post‑meal sugar control.

Take exactly as prescribed by your doctor. Usually taken once daily with breakfast or the first main meal; swallow whole with water. Metformin-containing tablets are best taken with food to reduce stomach upset; do not skip meals to reduce risk of low sugar.

Hypoglycaemia (low blood sugar), nausea, vomiting, diarrhoea, abdominal discomfort, loss of appetite, headache, dizziness, taste disturbance

Risk of hypoglycaemia (especially with missed meals, alcohol, heavy exercise); monitor blood glucose regularly. Metformin may rarely cause lactic acidosis—risk increases with kidney disease, severe dehydration, severe infection, shock, or excessive alcohol. Not recommended in severe renal impairment; kidney function should be assessed before and during therapy. Inform doctor before surgery or iodinated contrast imaging—metformin may need to be stopped temporarily. Use caution in liver disease and in elderly patients.

Alcohol (increases risk of hypoglycaemia and lactic acidosis), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia symptoms), corticosteroids and thiazide diuretics (raise blood sugar), ACE inhibitors (may increase hypoglycaemic effect), fluoroquinolones (glucose disturbances), cimetidine and other drugs affecting kidney tubular secretion (increase metformin levels), iodinated contrast media (risk of kidney injury/lactic acidosis)

Store below 25°C in a cool, dry place away from moisture and direct light. Keep out of reach of children.

Amaryl M 1 Tablet, Glycomet-GP 1 Tablet, Glimy M 1 Tablet, Glime-M 1 Tablet, Glimet 1 Tablet