Glimapex-M1 Tab

Tablet

Type 2 diabetes mellitus in adults, especially when diet and exercise alone or single-drug therapy do not provide adequate glycaemic control

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves insulin sensitivity. Metformin reduces glucose production by the liver and decreases intestinal glucose absorption while improving peripheral insulin uptake. Together they lower fasting and post-meal blood sugar.

Oral tablet. Take exactly as prescribed, usually once daily with breakfast or the first main meal (or as advised). Swallow whole (do not crush/chew if extended-release). Regularly monitor blood glucose; follow diet and exercise plan.

Hypoglycaemia, nausea, vomiting, diarrhoea, abdominal discomfort, loss of appetite, headache, dizziness, weight gain, metallic taste

Risk of hypoglycaemia (higher with missed meals, alcohol, strenuous exercise, elderly); metformin-associated lactic acidosis is rare but serious—risk increases with kidney impairment, dehydration, severe infection, hypoxia, heart failure, liver disease, or excess alcohol. Check renal function before starting and periodically; avoid in severe renal impairment. Withhold metformin temporarily before/after iodinated contrast procedures and major surgery as advised. Use caution when driving/operating machinery due to hypoglycaemia risk.

Alcohol (increases hypoglycaemia and lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (may mask hypoglycaemia symptoms), corticosteroids/thiazide diuretics (may raise glucose), ACE inhibitors (may increase hypoglycaemia risk), NSAIDs and sulfonamides (may increase hypoglycaemia), cimetidine (may increase metformin levels), iodinated contrast media (risk of lactic acidosis—temporary stoppage), quinolones (glucose disturbances)

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

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