Glimigrand M2 Tab

Tablet

Type 2 diabetes mellitus (adult) when diet and exercise alone or single therapy is inadequate; helps control high blood sugar

Glimepiride (a sulfonylurea) stimulates the pancreas to release insulin and improves the body’s response to insulin. Metformin (a biguanide) reduces glucose production in the liver and decreases intestinal absorption of glucose while improving insulin sensitivity.

Take orally as prescribed, usually once daily with breakfast or the first main meal. Swallow the tablet whole (especially if SR/PR); do not crush or chew. Monitor blood glucose regularly and follow diet/exercise advice.

Hypoglycaemia, dizziness, headache, nausea, diarrhoea, abdominal discomfort, metallic taste, decreased appetite, weight gain (with sulfonylurea)

Risk of hypoglycaemia (especially with missed meals, alcohol, strenuous exercise, elderly, or kidney/liver impairment); lactic acidosis risk with metformin (more likely in severe kidney disease, dehydration, severe infection, shock, alcohol misuse). Contraindicated in severe renal impairment; assess kidney function before and during therapy. Temporarily stop metformin before/after iodinated contrast procedures and major surgery as advised. Use caution in hepatic impairment and in patients with heart failure. Seek urgent care for symptoms of low sugar or lactic acidosis (unusual tiredness, muscle pain, rapid breathing, abdominal pain).

Alcohol (increases hypoglycaemia and lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), corticosteroids and thiazide diuretics (may raise glucose), beta-blockers (may mask hypoglycaemia symptoms), ACE inhibitors (may enhance glucose-lowering), quinolones (may alter glucose), rifampicin (may reduce sulfonylurea effect), azole antifungals/macrolides (may increase glimepiride effect), iodinated contrast media (increases lactic acidosis risk with metformin)

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep out of reach of children.

Amaryl M 2 Tablet, Glimy M2 Tablet, Glycomet-GP 2 Tablet SR, Glime M2 Tablet, Gluconorm-G 2 Tablet