Itraban 100 mg Capsule

Itraban 100 mg Capsule contains Itraconazole 100 mg (capsule). Prescription required.

Treatment of fungal infections such as aspergillosis, histoplasmosis, blastomycosis, candidiasis, tinea (ringworm), athlete’s foot, jock itch, and pityriasis versicolor; may be used for onychomycosis (nail fungal infection) as prescribed.

Itraconazole is a triazole antifungal that inhibits fungal cytochrome P450 enzyme (14-α demethylase), blocking ergosterol synthesis. This disrupts the fungal cell membrane, inhibiting growth and leading to clearance of infection.

Take orally exactly as prescribed. Capsules should be taken with food (improves absorption) and swallowed whole. Complete the full course; do not stop early even if symptoms improve.

Nausea, abdominal pain, diarrhoea, headache, dizziness, rash, elevated liver enzymes

Prescription medicine. Can cause serious liver injury—use caution in liver disease and monitor if prolonged therapy; stop and seek care if jaundice/dark urine/severe fatigue occurs. May worsen or precipitate heart failure (negative inotrope)—avoid in congestive heart failure unless benefits outweigh risks. Numerous drug interactions via CYP3A4—some combinations are contraindicated due to risk of dangerous arrhythmias. Avoid in known hypersensitivity to itraconazole. Use caution in kidney impairment.

Contraindicated/avoid with drugs highly dependent on CYP3A4 (risk of QT prolongation/arrhythmia) such as certain antiarrhythmics (e.g., quinidine, dofetilide), some antihistamines (e.g., terfenadine/astemizole—where applicable), cisapride, and ergot alkaloids; increases levels of statins (simvastatin/lovastatin), benzodiazepines (midazolam/triazolam), calcium channel blockers, digoxin, warfarin and some oral hypoglycaemics; reduced absorption with antacids, PPIs/H2 blockers (separate dosing); rifampicin/rifabutin, phenytoin, carbamazepine, St John’s wort reduce effect; caution with other QT-prolonging drugs.

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

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