Lonazep 0.25 Tablet

Drug | Tablet

Treatment of anxiety and panic disorder; adjunct treatment of certain seizure disorders/epilepsy (as prescribed).

Clonazepam is a benzodiazepine that enhances the effect of GABA, an inhibitory neurotransmitter in the brain. This reduces excessive nerve activity, helping relieve anxiety/panic symptoms and preventing seizures.

Tablet for oral use. Take exactly as prescribed, preferably at the same time each day. It can be taken with or without food; if stomach upset occurs, take with food. Do not stop suddenly—dose should be tapered by a doctor.

Drowsiness, dizziness, fatigue, impaired coordination (ataxia), slowed thinking, confusion, memory problems, slurred speech

May cause sedation, impaired coordination and falls—avoid driving or operating machinery. Risk of dependence, misuse and withdrawal; do not stop abruptly. Use with caution in liver disease, respiratory disorders (e.g., COPD, sleep apnea), depression/suicidal thoughts, elderly patients. Concomitant use with opioids or other CNS depressants can cause profound sedation and respiratory depression. Not recommended in acute narrow-angle glaucoma; caution in history of substance abuse.

Alcohol and other CNS depressants (opioids, sedating antihistamines, antipsychotics) increase sedation/respiratory depression; other antiepileptics (e.g., valproate, carbamazepine, phenytoin) may alter levels/effects; CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) may increase clonazepam effects; CYP inducers (e.g., rifampicin) may reduce effect.

Store below 25°C, protected from light and moisture. Keep in original pack and out of reach of children.

Rivotril 0.25 Tablet, Clonotril 0.25 Tablet, Sizodon 0.25 Tablet, Zapiz 0.25 Tablet, Nexito Plus (only if clinically appropriate; different combo)