Mezolam Injection

Drug | Injection

Short-term sedation and anxiolysis before procedures, induction and maintenance of anesthesia, procedural sedation, ICU sedation, status epilepticus/acute seizures (as per physician)

Midazolam is a benzodiazepine that enhances the effect of GABA at the GABA-A receptor in the brain. This increases inhibitory neurotransmission, producing sedation, anxiolysis, muscle relaxation and anticonvulsant effects.

Injection to be administered only by trained healthcare professionals in a hospital/clinical setting. Dose and rate depend on indication, age, weight and clinical status; given IV/IM as directed. Continuous monitoring of breathing, oxygen saturation, BP and heart rate is required; avoid driving/operating machinery after receiving it.

Drowsiness,sedation,dizziness,confusion,amnesia,low blood pressure,slow/irregular breathing,apnea,nausea,vomiting,injection site pain

Schedule H1 medicine: use only on prescription under medical supervision. Can cause profound sedation, respiratory depression, apnea and hypotension—higher risk with opioids, alcohol, other sedatives, elderly, debilitated patients, sleep apnea, COPD or severe illness. Use caution in liver impairment; effects may be prolonged. Risk of paradoxical reactions (agitation, aggression) and anterograde amnesia. Potential for dependence/withdrawal with prolonged or repeated use; taper if used for extended periods. Not recommended to self-administer.

Opioids (morphine,fentanyl,codeine,tramadol) and other CNS depressants (alcohol,antihistamines,antipsychotics,sedative antidepressants) increase respiratory depression. CYP3A4 inhibitors (ketoconazole,itraconazole,fluconazole,clarithromycin,erythromycin,ritonavir/cobicistat,grapefruit) increase midazolam levels; CYP3A4 inducers (rifampicin,carbamazepine,phenytoin,phenobarbital,St John’s wort) reduce effect. Caution with antihypertensives due to hypotension.

Store below 25°C in original carton, protected from light. Do not freeze. Keep out of reach of children.

Midazolam Injection (various brands),Dormicum Injection,Midaz Injection,Mezolam 5 mg/5 mL Injection (same brand strength variant if available),Midazolam 1 mg/mL 10 mL Injection (generic)