Tapal ER 100 Tab

Tablet

Management of moderate to severe chronic pain requiring continuous, around-the-clock opioid analgesia for an extended period (e.g., chronic musculoskeletal/neuropathic pain) when alternative treatment options are inadequate.

Tapentadol is a centrally acting analgesic with dual action: it is a mu-opioid receptor agonist and inhibits norepinephrine reuptake. This reduces pain signal transmission and modulates descending inhibitory pain pathways.

Oral extended-release tablet. Take exactly as prescribed, usually every 12 hours; swallow whole with water (do not crush, break or chew). Can be taken with or without food; take at the same times each day. Do not stop suddenly without medical advice.

Nausea, vomiting, constipation, dizziness, drowsiness/somnolence, headache, dry mouth, itching, sweating, fatigue

Prescription opioid; risk of addiction, abuse and misuse. May cause serious/life-threatening respiratory depression—higher risk in elderly, debilitated patients, sleep apnea/COPD, and with other CNS depressants. Do not crush/chew ER tablets (overdose risk). Avoid driving/operating machinery due to drowsiness/dizziness. Use caution in head injury/increased intracranial pressure, seizure disorders, liver/kidney impairment, hypotension, biliary disease, and history of substance use disorder. May cause withdrawal in newborn if used long-term during pregnancy. Keep out of reach of children.

Alcohol and other CNS depressants (benzodiazepines, sedatives, hypnotics, antipsychotics, other opioids), MAO inhibitors (contraindicated/avoid within 14 days), serotonergic drugs (SSRIs/SNRIs/TCAs/triptans/linezolid) and drugs affecting norepinephrine (risk of serotonin syndrome/adrenergic effects), strong CYP inducers/inhibitors may alter exposure, mixed agonist/antagonist opioids (may reduce effect/precipitate withdrawal)

Store at room temperature (below 25°C), protected from moisture and light, in original blister pack. Keep securely stored to prevent accidental ingestion/misuse.

Tapentadol ER 100 mg tablet (generic), Tydol ER 100 Tablet, Tapaday ER 100 Tablet, Tapanext ER 100 Tablet, Tapal ER 50 Tablet (dose variant)