Zoryl Ms Ir 1/500MG Tab

Tablet

Type 2 diabetes mellitus in adults when diet and exercise alone or single therapy is insufficient; helps control blood glucose levels.

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves insulin action. Metformin (a biguanide) reduces glucose production in the liver and improves insulin sensitivity, lowering blood sugar without usually causing hypoglycaemia when used alone.

Take by mouth as prescribed, usually once or twice daily with meals (preferably with breakfast and/or main meals) to reduce stomach upset and risk of low sugar. Swallow tablet with water; do not skip meals. Dose is individualized based on blood glucose; do not self-adjust.

Hypoglycaemia, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weight gain

Risk of hypoglycaemia (higher with missed meals, alcohol, heavy exercise, elderly, kidney/liver impairment). Metformin may rarely cause lactic acidosis—seek urgent care for rapid breathing, severe weakness, drowsiness, abdominal pain. Use caution/avoid in severe renal impairment, severe liver disease, alcohol misuse, dehydration, severe infection, shock, or hypoxia states; withhold around major surgery or iodinated contrast procedures as advised. Monitor kidney function, HbA1c, and blood glucose regularly.

Alcohol (increases hypoglycaemia and lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), sulfonamide antibiotics, fluoroquinolones, macrolides (may alter glucose), beta-blockers (mask hypoglycaemia), corticosteroids and thiazide diuretics (raise glucose), ACE inhibitors (may enhance glucose-lowering), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (raises metformin levels)

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep out of reach of children.

Glimy M 1 Tablet, Amaryl M 1 Tablet, Glimepiride+Metformin 1/500 Tablet (generic), Glycomet-GP 1/500 Tablet, Gemer M1 Tablet