Prescription requiredAnticancer (Antineoplastic)

A-Tret 25MG Cap — Side Effects & Warnings

Known side effects of A-Tret 25MG Cap include Headache, fever, skin rash, dry skin/lips, nausea, vomiting, diarrhea, abdominal pain, bone/joint pain, fatigue, peripheral edema, elevated liver enzymes, increased blood lipids. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated July 2026

Common Side Effects

Headache
fever
skin rash
dry skin/lips
nausea
vomiting
diarrhea
abdominal pain
bone/joint pain
fatigue
peripheral edema
elevated liver enzymes
increased blood lipids

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

For use only under specialist (oncology/hematology) supervision. Risk of ATRA (differentiation) syndrome/retinoic acid syndrome (fever, breathing difficulty, weight gain, edema, low blood pressure) which can be life-threatening—seek urgent care. Highly teratogenic: strict pregnancy prevention required; avoid in pregnancy and do not breastfeed. Monitor CBC, liver function, lipids, and for blood clots; caution in hepatic impairment, hyperlipidemia, and pancreatitis risk. May cause dizziness/visual disturbances—use caution while driving. Avoid vitamin A supplements to reduce toxicity.

Drug Interactions

A-Tret 25MG Cap may interact with the following:

Tetracyclines (risk of increased intracranial pressure)
vitamin A/other retinoids (additive toxicity)
azole antifungals (e.g.
ketoconazole/itraconazole) and macrolides (may increase levels)
CYP inducers (e.g.
rifampicin
phenytoin
carbamazepine
phenobarbital) may reduce effect
drugs increasing thrombotic risk (e.g.
hormonal contraceptives)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Not recommended (contraindicated in pregnancy); strict contraception required

Alcohol Interaction

Use with caution (may worsen liver effects and raise triglycerides)

Habit Forming

Storage

Store below 25°C, protected from light and moisture. Keep in original blister pack. Keep out of reach of children.

A-Tret 25MG Cap — Safety Summary

Composition: Tretinoin (All-trans retinoic acid) 25 mg capsule
Prescription: Required (Rx)
Pregnancy: Not recommended (contraindicated in pregnancy); strict contraception required
Alcohol: Use with caution (may worsen liver effects and raise triglycerides)
Habit forming: No

A-Tret 25MG Cap — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.

A-Tret 25MG Cap — Side Effects & Warnings

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated July 2026