A-Tret 25 mg Capsule

Composition of A-Tret 25 mg Capsule

A-Tret 25 mg Capsule contains Tretinoin (All-trans retinoic acid) 25 mg capsule. It belongs to the Retinoid (Differentiation agent; all-trans retinoic acid) class of medicines.

Uses of A-Tret 25 mg Capsule

• Treatment of acute promyelocytic leukemia (APL
• M3 subtype) in patients with t(15;17) / PML-RARA
• typically for induction of remission under specialist supervision

Key benefits

• Induces remission in acute promyelocytic leukemia
• Promotes differentiation of leukemic promyelocytes
• Reduces abnormal blast cells
• Used as part of standard APL induction regimens

How A-Tret 25 mg Capsule works

Tretinoin is a retinoid that binds to retinoic acid receptors and promotes differentiation and maturation of malignant promyelocytes. In APL it helps overcome the differentiation block caused by the PML-RARA fusion, reducing abnormal blasts and helping restore normal blood cell development.

How to take A-Tret 25 mg Capsule

Oral capsule. Dose and duration are strictly as prescribed by an oncologist (commonly weight-based in APL). Swallow whole with water, preferably with food to improve absorption; take at the same times each day. Do not crush or open the capsule.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe irritation when far too much cream is applied; an oral retinoid taken in excess can cause headache, vomiting and liver injury. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of A-Tret 25 mg Capsule

Most side effects of A-Tret are mild and settle as the body adjusts. Reported side effects include:

• Headache
• fever
• skin rash
• dry skin/lips
• nausea
• vomiting
• diarrhea
• abdominal pain
• bone/joint pain
• fatigue
• peripheral edema
• elevated liver enzymes
• increased blood lipids

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for A-Tret 25 mg Capsule

Warnings and precautions

For use only under specialist (oncology/hematology) supervision. Risk of ATRA (differentiation) syndrome/retinoic acid syndrome (fever, breathing difficulty, weight gain, edema, low blood pressure) which can be life-threatening—seek urgent care. Highly teratogenic: strict pregnancy prevention required; avoid in pregnancy and do not breastfeed. Monitor CBC, liver function, lipids, and for blood clots; caution in hepatic impairment, hyperlipidemia, and pancreatitis risk. May cause dizziness/visual disturbances—use caution while driving. Avoid vitamin A supplements to reduce toxicity.

Do not take A-Tret if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Oral retinoids are absolutely contraindicated in pregnancy and in anyone who might become pregnant without a pregnancy prevention programme. Topical retinoids are avoided in pregnancy.

Interactions with other medicines

Tetracyclines (risk of increased intracranial pressure), vitamin A/other retinoids (additive toxicity), azole antifungals (e.g., ketoconazole/itraconazole) and macrolides (may increase levels), CYP inducers (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital) may reduce effect, drugs increasing thrombotic risk (e.g., hormonal contraceptives)

How to store A-Tret 25 mg Capsule

Store below 25°C, protected from light and moisture. Keep in original blister pack. Keep out of reach of children.

Expert advice for A-Tret 25 mg Capsule

Apply retinoids at night to clean, dry skin, and moisturise afterwards. Give it at least eight to twelve weeks before judging whether it works. Do not pick or squeeze spots — that is what leaves scars.

Manufacturer and class

Manufacturer:

KAIZEN LABORATORIES PVT LTD.`

Therapeutic class:

Anticancer (Antineoplastic)

Drug class:

Retinoid (Differentiation agent; all-trans retinoic acid)