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Prescription requiredMsn LaboratoriesUrology (BPH/Overactive bladder therapy)
Silotrif M 50 Tablet
Silodosin (8mg) + Mirabegron (50mg)
₹459MRP ₹483In stock
Delivery across India. Free above ₹999; ₹49 from ₹499, ₹99 below. Chennai express delivery is chargeable.
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Silotrif M 50 Tablet is used for treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) such as weak urine stream, hesitancy, incomplete bladder emptying; management of overactive bladder symptoms (urgency, frequency, urge incontinence) when present along with BPH/LUTS.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Licensed pharmacyPharmacist-verified orderDelivered across India
Key details
Salt: Silodosin (8mg) + Mirabegron (50mg)
Available variants: tablet 8mg + 50mg 10`S
Best price: ₹459 (₹45.87 per tablet)
MRP: ₹483
Prescription: Required
Manufacturer: MSN LABORATORIES
Ordering notes
Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
Composition of Silotrif M 50 Tablet
Silotrif M 50 Tablet contains Silodosin (8mg) + Mirabegron (50mg). It belongs to the Alpha-1A adrenergic blocker + Beta-3 adrenergic agonist class of medicines.
Uses of Silotrif M 50 Tablet
- Treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) such as weak urine stream
- hesitancy
- incomplete bladder emptying; management of overactive bladder symptoms (urgency
- frequency
- urge incontinence) when present along with BPH/LUTS.
Key benefits
- Improves urine flow in BPH
- Reduces urinary urgency and frequency
- Helps decrease nocturia
- Relieves hesitancy and incomplete emptying
- Improves quality of life in LUTS
How Silotrif M 50 Tablet works
Silodosin is a selective alpha-1A adrenergic blocker that relaxes smooth muscle in the prostate and bladder neck to improve urine flow and reduce obstruction symptoms. Mirabegron is a beta-3 adrenergic agonist that relaxes the bladder detrusor during the storage phase, increasing bladder capacity and reducing urgency/frequency.
How to take Silotrif M 50 Tablet
Take as prescribed by the doctor. Usually taken once daily with food, preferably at the same time each day. Swallow the tablet whole with water; do not crush or chew. If a dose is missed, take it when remembered unless it is close to the next dose; do not double.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Missed dose and overdose
If you miss a dose
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
If you take too much
An overdose of this medicine may be harmful — seek medical advice immediately. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Side effects of Silotrif M 50 Tablet
Most side effects of Silotrif M are mild and settle as the body adjusts. Reported side effects include:
- Dizziness
- headache
- orthostatic hypotension (drop in BP on standing)
- nasal congestion
- retrograde ejaculation/ejaculation disorders
- diarrhea
- nausea
- constipation
- dry mouth
- palpitations
- increased blood pressure
- urinary retention
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Silotrif M 50 Tablet
| Pregnancy | Not recommended (intended for use in men; consult doctor if prescribed otherwise) |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Use with caution (may increase dizziness/low blood pressure) |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Use with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function. |
| Liver | Use with caution if you have liver disease — your doctor may adjust the dose or monitor your liver function. |
| Habit forming | No |
Warnings and precautions
For men with BPH/LUTS: may cause dizziness/fainting due to low blood pressure—rise slowly and use caution when driving. Mirabegron can increase blood pressure; monitor BP especially in patients with hypertension and avoid/use with caution in severe uncontrolled hypertension. Risk of urinary retention, especially in bladder outlet obstruction and when combined with antimuscarinics—seek help if unable to pass urine. Dose adjustment/caution may be needed in kidney or liver impairment; avoid strong CYP3A4 inhibitors with silodosin in some patients. Tell eye surgeon before cataract/glaucoma surgery (risk of intraoperative floppy iris syndrome with alpha-blockers).
Do not take Silotrif M if
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Your doctor will confirm this medicine is suitable for you.
Interactions with other medicines
Strong CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin) may increase silodosin levels; other alpha-blockers or antihypertensives may increase risk of low BP; PDE5 inhibitors (sildenafil, tadalafil) may enhance hypotensive effect; mirabegron (CYP2D6 inhibitor) can increase levels of metoprolol, desipramine, flecainide, propafenone, thioridazine; digoxin levels may increase (monitor); caution with drugs that raise BP.
How to store Silotrif M 50 Tablet
Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.
Expert advice for Silotrif M 50 Tablet
Take it at the same time each day and complete the course. Keep your follow-up appointments and any monitoring blood tests.
Manufacturer and class
- Manufacturer:
- MSN LABORATORIES
- Therapeutic class:
- Urology (BPH/Overactive bladder therapy)
- Drug class:
- Alpha-1A adrenergic blocker + Beta-3 adrenergic agonist
Substitutes for Silotrif M 50 Tablet
Medicines with the same active ingredient (Silodosin (8mg) + Mirabegron (50mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Silotrif M 50 Tablet |
|---|---|---|---|
| Silotrif 4 mg CapsuleMSN LABORATORIES | capsule · 15`S | ₹251 | 45% cheaper |
| Silotime M 50 TabletIntas Pharmaceuticals Ltd | tablet · 10`S | ₹539 | 17% more |
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Silotrif M 50 Tablet FAQs
What is Silotrif M 50 Tablet used for?
Silotrif M 50 Tablet is commonly used for Treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) such as weak urine stream, hesitancy, incomplete bladder emptying; management of overactive bladder symptoms (urgency, frequency, urge incontinence) when present along with BPH/LUTS. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Silotrif M 50 Tablet?
Silotrif M 50 Tablet contains Silodosin (8mg) + Mirabegron (50mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Silotrif M 50 Tablet?
Take as prescribed by the doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Silotrif M 50 Tablet work?
Silodosin is a selective alpha-1A adrenergic blocker that relaxes smooth muscle in the prostate and bladder neck to improve urine flow and reduce obstruction symptoms.
Is Silotrif M 50 Tablet a prescription medicine?
Yes. Silotrif M 50 Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Silotrif M 50 Tablet?
The side effects reported most often with Silotrif M are Dizziness, headache, orthostatic hypotension (drop in BP on standing), nasal congestion, retrograde ejaculation/ejaculation disorders. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Silotrif M 50 Tablet be taken during pregnancy?
Not recommended (intended for use in men; consult doctor if prescribed otherwise) Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Silotrif M.
Can I drink alcohol while taking Silotrif M 50 Tablet?
Use with caution (may increase dizziness/low blood pressure)
What if I miss a dose of Silotrif M 50 Tablet?
Take it as soon as you remember.
Is Silotrif M 50 Tablet habit forming?
No. Silotrif M 50 Tablet is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Silotrif M 50 Tablet?
Silotrif 4 mg Capsule has the same active ingredient and strength and is listed from ₹251 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Silotrif M 50 Tablet cost on PingMeDoc Pharmacy?
Silotrif M 50 Tablet starts at ₹459 (MRP ₹483) on PingMeDoc Pharmacy. Available in tablet 8mg + 50mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Silotrif M 50 Tablet?
Silotrif M 50 Tablet is manufactured by MSN LABORATORIES. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Silotrif M 50 Tablet delivered?
Silotrif M 50 Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.
Silotrif M 50 Tablet, Quick facts
- Salt
- Silodosin (8mg) + Mirabegron (50mg)
- Form
- tablet
- Best price
- ₹459 (₹45.87 per tablet)
- MRP
- ₹483
- Prescription
- Required (Rx)
- Schedule
- Schedule H
- Brand
- MSN LABORATORIES
- Manufacturer
- MSN LABORATORIES
- Therapeutic class
- Urology (BPH/Overactive bladder therapy)
- Drug class
- Alpha-1A adrenergic blocker + Beta-3 adrenergic agonist
- Habit forming
- No
- Variants
- tablet 8mg + 50mg 10`S
- Delivery
- Standard across India
References
The information on Silotrif M 50 Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.
- Manufacturer labeling/pack insert, established medical literature (drug monographs), regulatory/standard references used in India (e.g.
- CDSCO labeling norms)
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Silotrif M 50 Tablet.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.