Sitaforce M 50/500

Composition of Sitaforce M 50/500

Sitaforce M 50/500 contains Sitagliptin 50 mg + Metformin hydrochloride 500 mg. It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Sitaforce M 50/500

• Type 2 diabetes mellitus (to improve glycaemic control along with diet and exercise)
• especially when metformin alone is inadequate

Key benefits

• Helps lower fasting and post-meal blood sugar
• Improves HbA1c control
• Low risk of hypoglycaemia when not combined with insulin/sulfonylurea
• Supports insulin sensitivity and reduces liver glucose output
• Convenient combination therapy to reduce pill burden

How Sitaforce M 50/500 works

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), boosting glucose-dependent insulin release and reducing glucagon. Metformin decreases hepatic glucose production and improves insulin sensitivity, lowering blood glucose without usually causing hypoglycaemia when used alone.

How to take Sitaforce M 50/500

Oral tablet. Take as prescribed, usually twice daily with meals to reduce stomach upset. Swallow whole with water; do not crush/chew. Follow diet/exercise plan and monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine may cause low blood sugar, particularly if you also take other diabetes medicines. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Sitaforce M 50/500

Most side effects of Sitaforce M 50/500 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• headache
• dizziness
• upper respiratory tract infection
• nasopharyngitis

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Sitaforce M 50/500

Warnings and precautions

Not for type 1 diabetes or diabetic ketoacidosis. Metformin can rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, heart failure, heavy alcohol use, or hypoxia; assess renal function before and during therapy. Stop temporarily before/after iodinated contrast or major surgery as advised. Sitagliptin may rarely cause pancreatitis, severe joint pain, allergic reactions, or bullous pemphigoid—seek care if severe abdominal pain or rash. Use caution in elderly and in hepatic impairment.

Do not take Sitaforce M 50/500 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cationic drugs affecting renal tubular secretion (e.g., cimetidine), diuretics, ACE inhibitors/ARBs, corticosteroids, thyroid hormones, sympathomimetics, oral contraceptives, other antidiabetics/insulin (increased hypoglycaemia risk)

How to store Sitaforce M 50/500

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Expert advice for Sitaforce M 50/500

It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

LATIN LABS PRIVATE LIMITED

Therapeutic class:

prescription

Drug class:

DPP-4 inhibitor + Biguanide