Ziasit-D 100/10 mg Tablet

Composition of Ziasit-D 100/10 mg Tablet

Ziasit-D 100/10 mg Tablet contains Sitagliptin 100 mg + Dapagliflozin 10 mg. It belongs to the DPP-4 inhibitor + SGLT2 inhibitor class of medicines.

Uses of Ziasit-D 100/10 mg Tablet

Type 2 diabetes mellitus: to improve glycaemic control in adults as an adjunct to diet and exercise when treatment with both agents is appropriate.

Key benefits

• Lowers HbA1c and fasting/post-meal glucose
• Low hypoglycaemia risk when not combined with insulin/sulfonylurea
• Weight-neutral to modest weight loss
• Once-daily convenient combination
• May aid blood pressure reduction via mild diuresis

How Ziasit-D 100/10 mg Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), enhancing glucose-dependent insulin release and reducing glucagon. Dapagliflozin is an SGLT2 inhibitor that reduces renal glucose reabsorption, increasing urinary glucose excretion and lowering blood glucose.

How to take Ziasit-D 100/10 mg Tablet

Oral tablet; typically taken once daily as prescribed. Can be taken with or without food; take at the same time each day. Swallow whole with water; do not crush/chew. Dose adjustments may be needed in kidney impairment—follow doctor’s advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine may cause low blood sugar, particularly if you also take other diabetes medicines. It can cause dehydration and a fall in blood pressure. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Ziasit-D 100/10 mg Tablet

Most side effects of Ziasit-D 100/10 mg are mild and settle as the body adjusts. Reported side effects include:

• Genital fungal infection
• urinary tract infection
• increased urination
• thirst
• dehydration
• dizziness
• headache
• nasopharyngitis
• nausea

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Ziasit-D 100/10 mg Tablet

Warnings and precautions

Not for type 1 diabetes or diabetic ketoacidosis. Risk of dehydration/hypotension—ensure adequate fluids, especially in elderly or with diuretics. SGLT2 inhibitors may rarely cause ketoacidosis even with near-normal sugars—seek urgent care for nausea/vomiting, abdominal pain, rapid breathing. Increased risk of genital mycotic infections and UTIs; maintain hygiene and report symptoms. Monitor kidney function before and during therapy; avoid/initiate with caution in significant renal impairment as per prescriber. Rare risk of pancreatitis with sitagliptin—stop and seek care if severe persistent abdominal pain. Risk of hypoglycaemia when used with insulin or sulfonylureas—dose reduction of those agents may be required. Inform doctor before surgery/fasting; medicine may be temporarily stopped.

Do not take Ziasit-D 100/10 mg if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease.

Interactions with other medicines

Insulin and sulfonylureas (increased hypoglycaemia risk),diuretics (increased dehydration/hypotension risk),rifampicin and other strong enzyme inducers (may reduce sitagliptin levels),digoxin (sitagliptin may slightly increase levels—monitor),other SGLT2 inhibitors or DPP-4 inhibitors (duplicate therapy),alcohol/excessive intake (may increase dehydration/ketoacidosis risk)

How to store Ziasit-D 100/10 mg Tablet

Store below 25°C in a cool, dry place; protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Expert advice for Ziasit-D 100/10 mg Tablet

It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them. Take it in the morning so the extra urine does not disturb your sleep. Keep up your fluid intake and maintain genital hygiene. Tell any doctor treating you for an acute illness that you take this medicine.

Manufacturer and class

Manufacturer:

STATURE LIFE SCIENCES PRIVATE

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + SGLT2 inhibitor