Distributor inventory | Tablet

Type 2 diabetes mellitus: to improve glycaemic control in adults as an adjunct to diet and exercise when treatment with both agents is appropriate.

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), enhancing glucose-dependent insulin release and reducing glucagon. Dapagliflozin is an SGLT2 inhibitor that reduces renal glucose reabsorption, increasing urinary glucose excretion and lowering blood glucose.

Oral tablet; typically taken once daily as prescribed. Can be taken with or without food; take at the same time each day. Swallow whole with water; do not crush/chew. Dose adjustments may be needed in kidney impairment—follow doctor’s advice.

Genital fungal infection,urinary tract infection,increased urination,thirst,dehydration,dizziness,headache,nasopharyngitis,nausea

Not for type 1 diabetes or diabetic ketoacidosis. Risk of dehydration/hypotension—ensure adequate fluids, especially in elderly or with diuretics. SGLT2 inhibitors may rarely cause ketoacidosis even with near-normal sugars—seek urgent care for nausea/vomiting, abdominal pain, rapid breathing. Increased risk of genital mycotic infections and UTIs; maintain hygiene and report symptoms. Monitor kidney function before and during therapy; avoid/initiate with caution in significant renal impairment as per prescriber. Rare risk of pancreatitis with sitagliptin—stop and seek care if severe persistent abdominal pain. Risk of hypoglycaemia when used with insulin or sulfonylureas—dose reduction of those agents may be required. Inform doctor before surgery/fasting; medicine may be temporarily stopped.

Insulin and sulfonylureas (increased hypoglycaemia risk),diuretics (increased dehydration/hypotension risk),rifampicin and other strong enzyme inducers (may reduce sitagliptin levels),digoxin (sitagliptin may slightly increase levels—monitor),other SGLT2 inhibitors or DPP-4 inhibitors (duplicate therapy),alcohol/excessive intake (may increase dehydration/ketoacidosis risk)

Store below 25°C in a cool, dry place; protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Istamet D 100/10 Tablet,Forxiga Sita 100/10 Tablet,Qtern 10/5 Tablet (dapagliflozin+saxagliptin),Glyxambi 10/5 Tablet (empagliflozin+linagliptin),Jardiance Duo 10/5 Tablet (empagliflozin+linagliptin)