Zoryl Ms Ir 1/1000

Composition of Zoryl Ms Ir 1/1000

Zoryl Ms Ir 1/1000 contains Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg). It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Zoryl Ms Ir 1/1000

Type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient; used to improve blood glucose control.

Key benefits

• Helps lower fasting and post-meal blood sugar
• Improves insulin secretion and sensitivity
• May reduce insulin resistance-related glucose production
• Convenient combination therapy for Type 2 diabetes

How Zoryl Ms Ir 1/1000 works

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves peripheral glucose utilization. Metformin (a biguanide) reduces glucose production in the liver and improves insulin sensitivity, helping lower fasting and post‑meal blood sugar.

How to take Zoryl Ms Ir 1/1000

Take orally as prescribed, usually with/after meals to reduce stomach upset. Swallow tablet whole with water; do not crush unless advised. Monitor blood glucose regularly; dose is individualized based on control and tolerability.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zoryl Ms Ir 1/1000 as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zoryl Ms Ir 1/1000 than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zoryl Ms Ir 1/1000

Most side effects of Zoryl Ms Ir 1/1000 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• weight gain

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl Ms Ir 1/1000

Warnings and precautions

Risk of hypoglycaemia (especially with missed meals, alcohol, strenuous exercise, or with other antidiabetics); carry glucose source. Metformin can rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, heart/respiratory failure, or heavy alcohol use. Avoid/adjust in renal impairment; check eGFR before and during therapy. Temporarily stop metformin before iodinated contrast procedures or major surgery as advised. Use caution in liver disease; may cause vitamin B12 deficiency with long-term use. Not for type 1 diabetes or diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases hypoglycaemia/lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia symptoms), corticosteroids/thiazides (raise glucose), ACE inhibitors (may enhance glucose-lowering), rifampicin (reduces sulfonylurea effect), azole antifungals/fluoroquinolones/salicylates (may increase hypoglycaemia), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (raises metformin levels)

How to store Zoryl Ms Ir 1/1000

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide