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Prescription requiredIntas Pharmaceuticals LtdAntidiabetic
Zoryl Ms Ir 1/1000
Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg)
₹140MRP ₹1475% offIn stock
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Zoryl Ms Ir 1/1000 is used for type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient; used to improve blood glucose control.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Licensed pharmacyPharmacist-verified orderDelivered across India
Key details
Salt: Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg)
Available variants: NA 10`S
Best price: ₹140
MRP: ₹147
Prescription: Required
Manufacturer: INTAS PHARMACEUTICALS`
Ordering notes
Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
Composition of Zoryl Ms Ir 1/1000
Zoryl Ms Ir 1/1000 contains Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg). It belongs to the Sulfonylurea + Biguanide class of medicines.
Uses of Zoryl Ms Ir 1/1000
Type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient; used to improve blood glucose control.
Key benefits
- Helps lower fasting and post-meal blood sugar
- Improves insulin secretion and sensitivity
- May reduce insulin resistance-related glucose production
- Convenient combination therapy for Type 2 diabetes
How Zoryl Ms Ir 1/1000 works
Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves peripheral glucose utilization. Metformin (a biguanide) reduces glucose production in the liver and improves insulin sensitivity, helping lower fasting and post‑meal blood sugar.
How to take Zoryl Ms Ir 1/1000
Take orally as prescribed, usually with/after meals to reduce stomach upset. Swallow tablet whole with water; do not crush unless advised. Monitor blood glucose regularly; dose is individualized based on control and tolerability.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Missed dose and overdose
If you miss a dose
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
If you take too much
An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Side effects of Zoryl Ms Ir 1/1000
Most side effects of Zoryl Ms Ir 1/1000 are mild and settle as the body adjusts. Reported side effects include:
- Hypoglycaemia
- nausea
- vomiting
- diarrhoea
- abdominal pain
- loss of appetite
- metallic taste
- headache
- dizziness
- weight gain
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Zoryl Ms Ir 1/1000
| Pregnancy | Not recommended / Consult doctor |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Avoid |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Warnings and precautions
Risk of hypoglycaemia (especially with missed meals, alcohol, strenuous exercise, or with other antidiabetics); carry glucose source. Metformin can rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, heart/respiratory failure, or heavy alcohol use. Avoid/adjust in renal impairment; check eGFR before and during therapy. Temporarily stop metformin before iodinated contrast procedures or major surgery as advised. Use caution in liver disease; may cause vitamin B12 deficiency with long-term use. Not for type 1 diabetes or diabetic ketoacidosis.
Do not take Zoryl Ms Ir 1/1000 if
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.
Interactions with other medicines
Alcohol (increases hypoglycaemia/lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia symptoms), corticosteroids/thiazides (raise glucose), ACE inhibitors (may enhance glucose-lowering), rifampicin (reduces sulfonylurea effect), azole antifungals/fluoroquinolones/salicylates (may increase hypoglycaemia), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (raises metformin levels)
How to store Zoryl Ms Ir 1/1000
Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.
Expert advice for Zoryl Ms Ir 1/1000
Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them. It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them.
Manufacturer and class
- Manufacturer:
- INTAS PHARMACEUTICALS`
- Therapeutic class:
- Antidiabetic
- Drug class:
- Sulfonylurea + Biguanide
Substitutes for Zoryl Ms Ir 1/1000
Medicines with the same active ingredient (Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Zoryl Ms Ir 1/1000 |
|---|---|---|---|
| Obimet Gx-Sita 1/50/500 mg TabletCorona Remedies Pvt Ltd | tablet · 10`S | ₹88 | 37% cheaper |
| Sugaray gm 50/1/500 mg TabletLLOYD HEALTHCARE | tablet · 10`S | ₹118 | 16% cheaper |
| Glisen Sm 1 mg TabletALEMBIC PHARMA | tablet · 15`S | ₹220 | 57% more |
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Zoryl Ms Ir 1/1000 FAQs
What is Zoryl Ms Ir 1/1000 used for?
Zoryl Ms Ir 1/1000 is commonly used for Type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient; used to improve blood glucose control. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Zoryl Ms Ir 1/1000?
Zoryl Ms Ir 1/1000 contains Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Zoryl Ms Ir 1/1000?
Take orally as prescribed, usually with/after meals to reduce stomach upset. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Zoryl Ms Ir 1/1000 work?
Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves peripheral glucose utilization.
Is Zoryl Ms Ir 1/1000 a prescription medicine?
Yes. Zoryl Ms Ir 1/1000 is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Zoryl Ms Ir 1/1000?
The side effects reported most often with Zoryl Ms Ir 1/1000 are Hypoglycaemia, nausea, vomiting, diarrhoea, abdominal pain. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Zoryl Ms Ir 1/1000 be taken during pregnancy?
Not recommended / Consult doctor Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Zoryl Ms Ir 1/1000.
Can I drink alcohol while taking Zoryl Ms Ir 1/1000?
Avoid
What if I miss a dose of Zoryl Ms Ir 1/1000?
Take it as soon as you remember.
Is Zoryl Ms Ir 1/1000 habit forming?
No. Zoryl Ms Ir 1/1000 is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Zoryl Ms Ir 1/1000?
Obimet Gx-Sita 1/50/500 mg Tablet has the same active ingredient and strength and is listed from ₹88 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Zoryl Ms Ir 1/1000 cost on PingMeDoc Pharmacy?
Zoryl Ms Ir 1/1000 starts at ₹140 (MRP ₹147) on PingMeDoc Pharmacy. Available in NA 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Zoryl Ms Ir 1/1000?
Zoryl Ms Ir 1/1000 is manufactured by INTAS PHARMACEUTICALS`. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Zoryl Ms Ir 1/1000 delivered?
Zoryl Ms Ir 1/1000 is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.
Zoryl Ms Ir 1/1000, Quick facts
- Salt
- Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg)
- Best price
- ₹140
- MRP
- ₹147
- Prescription
- Required (Rx)
- Schedule
- Schedule H
- Brand
- Intas Pharmaceuticals Ltd
- Manufacturer
- INTAS PHARMACEUTICALS`
- Therapeutic class
- Antidiabetic
- Drug class
- Sulfonylurea + Biguanide
- Habit forming
- No
- Variants
- NA 10`S
- Delivery
- Standard across India
References
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered medical practitioner. It does not replace your own doctor's advice.
- Manufacturer labeling
- CDSCO/Indian regulatory labeling norms, established medical literature (standard pharmacology)
- Indian Pharmacopoeia (API standards)
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Zoryl Ms Ir 1/1000.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.