Acitrom 1 Tablet

Drug | Tablet

Prevention and treatment of blood clots (thromboembolism) such as deep vein thrombosis (DVT), pulmonary embolism (PE), prevention of stroke/systemic embolism in certain patients (e.g., atrial fibrillation), prevention of clotting after heart valve replacement

Acenocoumarol is a vitamin K antagonist anticoagulant. It inhibits vitamin K–dependent clotting factors (II, VII, IX, X), reducing the blood’s ability to form clots. Dose effect is monitored using INR and adjusted accordingly.

Take exactly as prescribed by the doctor at the same time each day, with or without food. Dose is individualized based on INR; do not change dose or stop abruptly without medical advice. If a dose is missed, take it as soon as remembered on the same day; do not double the next dose.

Bleeding, easy bruising, nosebleed, gum bleeding, blood in urine, black/tarry stools, nausea, vomiting, diarrhea, abdominal pain, rash, hair loss

High risk of bleeding—seek urgent care for unusual bleeding, severe headache, weakness, vomiting blood, black stools, or blood in urine. Requires regular INR monitoring and dose adjustments. Avoid sudden changes in dietary vitamin K intake (green leafy vegetables); keep intake consistent. Inform doctor before any surgery/dental procedures. Use caution in liver disease, kidney disease, uncontrolled hypertension, history of ulcers/bleeding, elderly, and patients prone to falls. Many medicines and herbal products can alter INR. Not recommended in pregnancy (especially first trimester) due to fetal risk; use only if specifically advised.

NSAIDs/aspirin and other antiplatelets (increased bleeding), heparin and other anticoagulants (increased bleeding), antibiotics (e.g., metronidazole, macrolides, fluoroquinolones, co-trimoxazole) and antifungals (e.g., fluconazole) (increase INR), amiodarone (increase INR), anticonvulsants like carbamazepine/phenytoin (may reduce or alter effect), rifampicin (reduces effect), thyroid hormones (increase effect), alcohol (affects INR), herbal products like ginkgo/garlic/St John’s wort (bleeding risk/INR changes)

Store at room temperature (below 25°C), protected from moisture and light. Keep in original pack and out of reach of children.

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