Strong CYP3A inhibitors (ketoconazole, clarithromycin, ritonavir), strong CYP3A inducers (rifampicin, carbamazepine, phenytoin), anticoagulants and other antiplatelets (warfarin, heparin, NOACs, clopidogrel) increase bleeding risk, NSAIDs increase bleeding risk, simvastatin/lovastatin high doses, digoxin (monitor levels)