Ceftisure Sb 1 5Gm | 218 5

Cefoperazone 1 g + Sulbactam 0.5 g (injection)

Moderate to severe bacterial infections such as intra-abdominal infections, respiratory tract infections, urinary tract infections, skin and soft tissue infections, gynecological infections, septicemia (as per susceptibility)

Cefoperazone is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis. Sulbactam is a beta-lactamase inhibitor that protects cefoperazone from enzymatic breakdown and extends activity against resistant bacteria. The combination improves coverage in mixed and resistant infections.

For IV/IM use only under medical supervision. Dose and frequency depend on severity, site of infection, liver/kidney function, and culture results. Complete the prescribed course.

Diarrhea, nausea, vomiting, injection site pain, rash, elevated liver enzymes, reduced platelets, positive Coombs test

Serious allergy risk in cephalosporin/penicillin allergy. Cefoperazone may increase bleeding risk and can cause hypoprothrombinemia; patients with malnutrition, liver disease, or prolonged therapy may need monitoring/vitamin K. Avoid alcohol during and for 72 hours after therapy due to possible disulfiram-like reaction. Use caution in liver impairment and biliary obstruction.

Alcohol (disulfiram-like reaction), anticoagulants/antiplatelets (bleeding risk), aminoglycosides (renal risk if co-administered), loop diuretics (kidney risk), oral contraceptives (antibiotics may reduce efficacy in some cases)