Itzoft 100MG Caps 10S

Capsule

Treatment of fungal infections such as dermatophytosis (tinea/ringworm), pityriasis versicolor, oral/vaginal candidiasis, and other susceptible systemic or superficial fungal infections as prescribed

Itraconazole is a triazole antifungal that inhibits fungal CYP450-dependent 14-α-demethylase, blocking ergosterol synthesis. This disrupts fungal cell membrane formation and inhibits fungal growth.

Capsule (oral): Take exactly as prescribed, usually once or twice daily. Take with food/after a full meal for better absorption; swallow whole and do not crush or chew. Complete the full course even if symptoms improve.

Nausea, vomiting, abdominal pain, diarrhoea, headache, dizziness, rash, elevated liver enzymes

Prescription-only antifungal. May cause liver injury—seek medical help if jaundice, dark urine, severe fatigue, or persistent nausea occurs; monitor LFTs if prolonged use. Not recommended in patients with heart failure/ventricular dysfunction (negative inotrope risk). Avoid in pregnancy unless clearly needed; use effective contraception during and for a period after therapy as advised. Avoid use in severe liver disease unless supervised. Itraconazole absorption is reduced by acid-suppressing medicines; take as directed if needed.

Strong CYP3A4 interactions: contraindicated/avoid with simvastatin/lovastatin, midazolam/triazolam (oral), ergot alkaloids, certain antiarrhythmics (e.g., quinidine, dofetilide), cisapride, pimozide. Levels affected by rifampicin/rifabutin, phenytoin, carbamazepine (reduce effect). Increases levels of warfarin, digoxin, cyclosporine/tacrolimus, some calcium channel blockers, benzodiazepines, and sulfonylureas. Reduced absorption with PPIs/H2 blockers/antacids.

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

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