Perinorm Tablet

Drug | Tablet

Treatment and prevention of nausea and vomiting (including due to migraine, medicines, or postoperative causes); symptomatic relief in gastro-oesophageal reflux and delayed gastric emptying (gastroparesis) where prescribed.

Metoclopramide is a dopamine (D2) receptor antagonist that acts on the vomiting centre/chemoreceptor trigger zone to reduce nausea and vomiting. It also increases gastrointestinal motility and speeds gastric emptying, helping relieve reflux and fullness.

Take as directed by the doctor, usually 30 minutes before meals and at bedtime if prescribed. Swallow the tablet with water; can be taken with or without food, but taking before meals is preferred for gastric-motility benefit. Use the lowest effective dose for the shortest duration; do not exceed prescribed frequency.

Drowsiness, dizziness, diarrhoea, restlessness (akathisia), fatigue, headache, dry mouth, abdominal cramps, extrapyramidal symptoms (muscle spasms/tremor)

May cause drowsiness—avoid driving or operating machinery if affected. Risk of extrapyramidal reactions (especially in children/young adults) and tardive dyskinesia with prolonged use—avoid long-term use unless specifically advised. Use with caution in Parkinson’s disease, epilepsy, depression, elderly patients, and in renal/hepatic impairment (dose adjustment may be needed). Contraindicated/avoid in GI obstruction, perforation or bleeding; and in pheochromocytoma. Seek urgent care for uncontrolled movements, fever/rigidity (neuroleptic malignant syndrome), or severe allergic reactions.

Levodopa/dopamine agonists (reduces effect), antipsychotics (increased extrapyramidal risk), serotonergic drugs/MAOIs/SSRIs (risk of serotonin syndrome), opioids and anticholinergics (reduce prokinetic effect), CNS depressants/alcohol (increased sedation), digoxin (reduced absorption), cyclosporine (increased levels), insulin (may require adjustment in diabetics with gastroparesis).

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Metoclopramide 10 mg Tablet (generic), Reglan 10 Tablet, Metoclopramide IP 10 mg Tablet, Perinorm 10 Tablet, Metoclopramide 10 Tablet (various brands)