Distributor inventory | Tablet

Ulcerative colitis (induction and maintenance of remission), Crohn’s disease (colonic involvement, as advised), Rheumatoid arthritis (disease-modifying treatment)

Sulfasalazine is broken down in the colon to 5-aminosalicylic acid (5-ASA) and sulfapyridine. 5-ASA reduces inflammation in the bowel lining, while sulfapyridine contributes to immunomodulatory/anti-inflammatory effects useful in rheumatoid arthritis.

Take by mouth exactly as prescribed. Swallow tablet whole; do not crush or chew (delayed-release). Take after food with a full glass of water; maintain adequate hydration. Doses are usually divided through the day; follow your doctor’s schedule.

Nausea, vomiting, loss of appetite, abdominal pain, headache, dizziness, rash, fever, reversible low sperm count, orange/yellow discoloration of urine/skin, mouth ulcers

Prescription medicine. Avoid if allergic to sulfonamides or salicylates. Monitor CBC and liver function periodically; risk of bone marrow suppression, hepatitis, and severe skin reactions (SJS/TEN). Use with caution in liver/kidney disease, asthma, G6PD deficiency, and in patients with blood dyscrasias. Stop and seek care if sore throat/fever, unusual bruising/bleeding, severe rash, jaundice, or breathing difficulty occurs. Ensure folate supplementation may be advised, especially in long-term use.

Methotrexate (increased toxicity risk), azathioprine/6-mercaptopurine (myelosuppression risk), warfarin/anticoagulants (altered INR/bleeding risk), digoxin (reduced absorption), folic acid (reduced absorption), antibiotics altering gut flora (may reduce effect in colitis), other myelotoxic drugs (additive blood toxicity)

Store below 25°C, protected from light and moisture. Keep in original blister pack and out of reach of children.

Salazopyrin EN 500 Tablet, Sazo 500 Tablet, Sulfazin 500 Tablet, Sulfasalazine 500 mg Tablets (generic), Saaz 500 Tablet