Tri Azulix DS 2

Glimepiride (2mg) + Metformin (500mg) + Pioglitazone (15mg)

Type 2 diabetes mellitus in adults when blood sugar is not adequately controlled with diet, exercise and dual therapy; helps control post-meal and fasting glucose

Glimepiride (a sulfonylurea) increases insulin release from the pancreas. Metformin SR reduces glucose production in the liver and improves insulin sensitivity. Voglibose delays carbohydrate absorption in the intestine to reduce post-meal sugar spikes.

Take orally as prescribed, usually once daily with food (preferably with the first main meal). Swallow whole; do not crush or chew sustained-release tablets. Follow diet and exercise advice; monitor blood glucose regularly.

Nausea, vomiting, diarrhoea, abdominal pain, flatulence, loss of appetite, dizziness, headache, hypoglycaemia, weight gain

Risk of hypoglycaemia (higher with missed meals, alcohol, heavy exercise); carry glucose source. Metformin may rarely cause lactic acidosis—use caution/avoid in severe kidney disease, severe liver disease, dehydration, sepsis, hypoxia; stop temporarily before/after iodinated contrast or major surgery as advised. Voglibose may cause significant gas/diarrhoea; avoid in intestinal obstruction, inflammatory bowel disease or severe digestive disorders. Monitor kidney function, liver enzymes and HbA1c; use caution in elderly.

Alcohol (increases hypoglycaemia and lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia symptoms), corticosteroids/thiazide diuretics (raise glucose), ACE inhibitors (may enhance glucose lowering), rifampicin (reduces glimepiride effect), azole antifungals/macrolides (increase sulfonylurea effect), cimetidine (may increase metformin levels), iodinated contrast media (lactic acidosis risk), NSAIDs/salicylates (increase hypoglycaemia risk)

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

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