Zifi-O Dry Syrup

Zifi-O Dry Syrup contains Cefixime 50 mg/5 ml + Ofloxacin 50 mg/5 ml (dry syrup; after reconstitution). Prescription required.

Treatment of susceptible bacterial infections such as acute bacterial diarrhea/dysentery, enteric fever (typhoid) (as per physician), urinary tract infections, and respiratory tract infections where combination therapy is considered appropriate.

Cefixime is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis leading to bacterial death. Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase/topoisomerase IV, preventing DNA replication. Together they provide broad antibacterial coverage against susceptible organisms.

Dry syrup: reconstitute with boiled and cooled water up to the mark; shake well. Give the dose exactly as prescribed by the doctor (usually in 1–2 divided doses), with or without food; if stomach upset occurs, give after food. Shake well before each dose and complete the full course.

Nausea, vomiting, diarrhea, abdominal pain, indigestion, headache, dizziness, rash, altered taste

Prescription-only antibiotic; use only for bacterial infections and complete the course. Use with caution in kidney disease (dose adjustment may be needed), history of allergy to cephalosporins/penicillins, seizure disorders, and in patients with history of tendon disorders. Fluoroquinolones may rarely cause tendonitis/tendon rupture, peripheral neuropathy, CNS effects and QT prolongation; seek medical help if tendon pain, numbness/tingling, palpitations or severe dizziness occur. Stop and consult doctor if severe diarrhea occurs (risk of C. difficile). Avoid unnecessary use in children unless specifically prescribed; ofloxacin use in children is generally restricted due to effects on growing cartilage—use only when benefits outweigh risks as decided by physician.

Antacids or supplements containing magnesium/aluminium/calcium/iron/zinc (reduce ofloxacin absorption; separate by 2–4 hours), warfarin/anticoagulants (may increase bleeding risk), NSAIDs (may increase CNS stimulation/seizure risk with quinolones), other QT-prolonging drugs (increased arrhythmia risk), probenecid (may increase cephalosporin levels)

Store dry powder below 25°C in a dry place away from light. After reconstitution, store as per label (often in refrigerator or at room temperature as directed) and use within the recommended period (commonly 7–14 days); do not freeze. Keep the bottle tightly closed and out of reach of children.

Cefixime + Ofloxacin Dry Syrup (various brands), Zifi-O 100 Dry Syrup, Taxim-O Dry Syrup, Mahacef-O Dry Syrup, Cefolac-O Dry Syrup