Zita-Met 20/500 mg Tablet

Zita-Met 20/500 mg Tablet contains Teneligliptin 20 mg + Metformin Hydrochloride 500 mg (usually as sustained/extended release; verify pack). Prescription required.

Type 2 diabetes mellitus to improve blood glucose control in adults, as an adjunct to diet and exercise; used when metformin alone is inadequate or when switching to combination therapy.

Teneligliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), enhancing glucose-dependent insulin release and reducing glucagon secretion. Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity, lowering fasting and post-meal glucose.

Oral tablet. Take exactly as prescribed, usually once daily with food (preferably with the main meal) to reduce stomach upset. Swallow whole if SR/ER; do not crush or chew. Monitor blood glucose regularly.

nausea, vomiting, diarrhea, abdominal discomfort, loss of appetite, headache, dizziness, nasopharyngitis, hypoglycaemia (especially with insulin/sulfonylureas), taste disturbance

Not for type 1 diabetes or diabetic ketoacidosis. Risk of lactic acidosis with metformin—seek urgent care for rapid breathing, severe weakness, abdominal pain, or unusual sleepiness; higher risk with kidney impairment, dehydration, severe infection, alcohol use, liver disease, or heart failure. Check renal function before and during therapy; dose adjustment/avoid in significant renal impairment. Temporarily stop metformin around iodinated contrast procedures and major surgery as advised by doctor. Monitor for pancreatitis (severe abdominal pain), hypersensitivity reactions, and vitamin B12 deficiency with long-term use.

Alcohol (increases lactic acidosis risk), insulin and sulfonylureas (increased hypoglycaemia risk), iodinated contrast media (renal risk/lactic acidosis—hold metformin), carbonic anhydrase inhibitors such as topiramate/acetazolamide (metabolic acidosis risk), cimetidine (may increase metformin levels), corticosteroids/thiazide diuretics/sympathomimetics (may raise glucose), ACE inhibitors (may enhance glucose-lowering), strong CYP/P-gp modulators may affect teneligliptin exposure (clinical relevance varies).

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Teneligliptin 20 mg + Metformin 500 mg tablets (generic), Tenepride M 20/500 Tablet, Tenlimet 20/500 Tablet, Teneza-M 20/500 Tablet, Tenliza M 20/500 Tablet