Zitamet 20/1000 Tablet

Zitamet 20/1000 Tablet contains Teneligliptin 20 mg + Metformin Hydrochloride 1000 mg (Prolonged/Extended Release, if specified on pack). Prescription required.

Type 2 diabetes mellitus to improve blood glucose control along with diet and exercise, especially when control is inadequate with metformin alone or combination therapy is required

Teneligliptin is a DPP-4 inhibitor that increases incretin levels (GLP-1, GIP), thereby increasing insulin release and decreasing glucagon in a glucose-dependent manner. Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity, reducing blood glucose levels.

Take by mouth exactly as prescribed. Usually taken once daily with food (preferably with evening meal) to reduce stomach upset; if it is an extended-release tablet, swallow whole—do not crush/chew/split. Monitor blood glucose regularly.

Nausea, vomiting, diarrhoea, abdominal discomfort, loss of appetite, headache, dizziness, nasopharyngitis, hypoglycaemia (especially with insulin/sulfonylureas), taste disturbance

Prescription-only antidiabetic. Metformin may rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, alcohol use, heart/liver failure; assess renal function before and during therapy. Avoid/use with caution in severe renal impairment; temporarily stop around iodinated contrast procedures and major surgery as advised. DPP-4 inhibitors can rarely cause pancreatitis or severe joint pain; seek medical help for severe abdominal pain. Not for type 1 diabetes or diabetic ketoacidosis.

Alcohol (increases lactic acidosis risk), iodinated contrast media (risk of renal decline/lactic acidosis), carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cimetidine (may increase metformin levels), insulin/sulfonylureas (increased hypoglycaemia risk), diuretics/ACE inhibitors/NSAIDs (may affect renal function), corticosteroids and sympathomimetics (may raise glucose)

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

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