Glimedose M2 Tablet

Composition of Glimedose M2 Tablet

Glimedose M2 Tablet contains Glimepiride 2 mg + Metformin hydrochloride 500 mg (modified release). It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Glimedose M2 Tablet

Type 2 diabetes mellitus (in adults) when diet and exercise alone or single-agent therapy do not provide adequate glycaemic control

Key benefits

• Lowers blood sugar
• Improves HbA1c control
• Controls fasting and post-meal glucose
• Combination therapy in one tablet
• Helps reduce diabetes complications with good control

How Glimedose M2 Tablet works

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves insulin sensitivity. Metformin (a biguanide) reduces glucose production in the liver and decreases intestinal glucose absorption while improving peripheral glucose uptake.

How to take Glimedose M2 Tablet

Oral tablet; take exactly as prescribed. Usually taken once daily with or just after food (often with breakfast) to reduce stomach upset and risk of low sugar. Swallow whole (do not crush/chew if modified-release); monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Glimedose M2 Tablet

Most side effects of Glimedose M2 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• weight gain

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Glimedose M2 Tablet

Warnings and precautions

May cause hypoglycaemia—risk increases with missed meals, alcohol, heavy exercise, or with other antidiabetics; carry a glucose source. Metformin can rarely cause lactic acidosis—risk higher in kidney disease, dehydration, severe infection, heart/respiratory failure, liver disease, or heavy alcohol use; stop and seek care for rapid breathing, severe weakness, abdominal pain. Use with caution in renal impairment; kidney function should be assessed before and during treatment. Temporarily stop metformin before/after iodinated contrast procedures and during major surgery as advised. Not for type 1 diabetes or diabetic ketoacidosis.

Do not take Glimedose M2 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol, insulin and other antidiabetic medicines (increased hypoglycaemia risk), beta-blockers (may mask hypoglycaemia), ACE inhibitors (may enhance glucose-lowering), corticosteroids and thiazide/loop diuretics (may raise glucose), rifampicin (may reduce sulfonylurea effect), azole antifungals and macrolides (may increase sulfonylurea effect), cimetidine (may increase metformin levels), iodinated contrast media (lactic acidosis risk), NSAIDs/salicylates (may increase hypoglycaemia)

How to store Glimedose M2 Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep in original strip and out of reach of children.

Expert advice for Glimedose M2 Tablet

Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

MSV LIFESCIENCES

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide