Prescription requiredAntidiabetic

Istamet D Ir 5/50/1000 — Side Effects & Warnings

Known side effects of Istamet D Ir 5/50/1000 include Nausea,diarrhoea,abdominal pain,loss of appetite,headache,upper respiratory tract infection,nasopharyngitis,urinary tract infection,genital fungal infection,increased urination,dizziness. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Nausea
diarrhoea
abdominal pain
loss of appetite
headache
upper respiratory tract infection
nasopharyngitis
urinary tract infection
genital fungal infection
increased urination
dizziness

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Prescription-only antidiabetic. Risk of lactic acidosis with metformin (higher in kidney/liver impairment, dehydration, heavy alcohol use, severe infection, hypoxia); stop and seek care if unexplained tiredness, muscle pain, fast breathing, abdominal pain occur. Dapagliflozin may cause dehydration/low blood pressure, genital infections, UTI, ketoacidosis (can occur with normal sugars), and rare Fournier’s gangrene—seek urgent help for severe nausea/vomiting, abdominal pain, rapid breathing, genital/perineal pain/swelling/fever. Sitagliptin: rare pancreatitis and hypersensitivity. Monitor kidney function; dose/therapy adjustments may be needed in renal impairment. Temporarily withhold around major surgery/acute illness and before iodinated contrast as advised by doctor. Not for type 1 diabetes or diabetic ketoacidosis.

Drug Interactions

Istamet D Ir 5/50/1000 may interact with the following:

Insulin/sulfonylureas (increased hypoglycaemia risk)
diuretics and antihypertensives (increased dehydration/hypotension)
alcohol (increases lactic acidosis risk)
iodinated contrast media (risk of lactic acidosis—temporary stoppage of metformin)
cimetidine (may increase metformin levels)
digoxin (sitagliptin may increase digoxin levels)
carbonic anhydrase inhibitors e.g. topiramate/acetazolamide (increased acidosis risk)
NSAIDs/ACE inhibitors/ARBs (may affect kidney function—monitor)
other SGLT2 inhibitors or DPP-4 inhibitors (duplicate therapy)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Not recommended / Consult doctor (generally avoid SGLT2 inhibitors in pregnancy; metformin/sitagliptin only if clearly needed).

Alcohol Interaction

Avoid / Use with caution (alcohol increases risk of metformin-associated lactic acidosis).

Habit Forming

Storage

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep out of reach of children.

Istamet D Ir 5/50/1000 — Safety Summary

Composition: Dapagliflozin 5 mg + Sitagliptin 50 mg + Metformin Hydrochloride 1000 mg (Immediate-release) per tablet
Prescription: Required (Rx)
Pregnancy: Not recommended / Consult doctor (generally avoid SGLT2 inhibitors in pregnancy; metformin/sitagliptin only if clearly needed).
Alcohol: Avoid / Use with caution (alcohol increases risk of metformin-associated lactic acidosis).
Habit forming: No

Istamet D Ir 5/50/1000 — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.

Istamet D Ir 5/50/1000 — Side Effects & Warnings

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026