Prescription requiredAntidiabetic

Istamet D Ir 5/50/1000 — Uses, Dosage & Benefits

Istamet D Ir 5/50/1000 is used for Type 2 diabetes mellitus: to improve glycaemic control as an adjunct to diet and exercise when treatment with these medicines is appropriate..

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

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Active Ingredient / Composition

Dapagliflozin 5 mg + Sitagliptin 50 mg + Metformin Hydrochloride 1000 mg (Immediate-release) per tablet

What is Istamet D Ir 5/50/1000 used for?

Type 2 diabetes mellitus: to improve glycaemic control as an adjunct to diet and exercise when treatment with these medicines is appropriate.

How Istamet D Ir 5/50/1000 Works

Metformin decreases hepatic glucose production and improves insulin sensitivity. Sitagliptin (a DPP-4 inhibitor) increases incretin levels, enhancing glucose-dependent insulin release and reducing glucagon. Dapagliflozin (an SGLT2 inhibitor) increases urinary glucose excretion by blocking glucose reabsorption in the kidney.

Dosage & Directions

Oral tablet (IR). Take as prescribed by your doctor, usually with meals to reduce stomach upset. Swallow whole with water; do not crush/chew. Maintain adequate hydration; follow diet/exercise advice and monitor blood glucose.

Always follow your doctor's prescription. Do not self-medicate.

Key Benefits

Helps reduce fasting and post-meal blood sugar
Improves insulin sensitivity and lowers glucose production
Promotes glucose removal via urine
Low risk of hypoglycaemia when used without insulin/secretagogues
May support weight and blood pressure reduction due to SGLT2 action

Pregnancy

Not recommended / Consult doctor (generally avoid SGLT2 inhibitors in pregnancy; metformin/sitagliptin only if clearly needed).

Alcohol Interaction

Avoid / Use with caution (alcohol increases risk of metformin-associated lactic acidosis).

Istamet D Ir 5/50/1000 — Quick Facts

Composition: Dapagliflozin 5 mg + Sitagliptin 50 mg + Metformin Hydrochloride 1000 mg (Immediate-release) per tablet
Therapeutic class: Antidiabetic
Drug class: Biguanide + DPP-4 inhibitor + SGLT2 inhibitor
Prescription: Required (Rx)
Price: ₹105
Habit forming: No
Storage: Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep out of reach of children.

Istamet D Ir 5/50/1000 — Usage FAQs

How should I take this medicine?

Follow the dosage prescribed by your doctor. Do not alter the dose without medical advice.

Can I take this medicine without a prescription?

Prescription-required medicines need a valid Rx. OTC medicines can be purchased directly.

What if I miss a dose?

Take the missed dose as soon as you remember, unless it is close to your next scheduled dose. Do not double the dose.

How long does it take to show effect?

The time to show effect varies by medicine and condition. Consult your doctor for specific timelines.

Istamet D Ir 5/50/1000 — Uses, Dosage & Benefits

Active Ingredient / Composition

What is Istamet D Ir 5/50/1000 used for?

How Istamet D Ir 5/50/1000 Works

Dosage & Directions

Key Benefits

Pregnancy

Alcohol Interaction

Istamet D Ir 5/50/1000 — Quick Facts

Istamet D Ir 5/50/1000 — Usage FAQs

More from PingMeDoc™

Safety disclaimer

Istamet D Ir 5/50/1000 — Uses, Dosage & Benefits

Active Ingredient / Composition

What is Istamet D Ir 5/50/1000 used for?

How Istamet D Ir 5/50/1000 Works

Dosage & Directions

Key Benefits

Pregnancy

Alcohol Interaction

Istamet D Ir 5/50/1000 — Quick Facts

Istamet D Ir 5/50/1000 — Usage FAQs

More from PingMeDoc™

Safety disclaimer