Istamet D Ir 5/50/1000

Composition of Istamet D Ir 5/50/1000

Istamet D Ir 5/50/1000 contains Dapagliflozin 5 mg + Sitagliptin 50 mg + Metformin Hydrochloride 1000 mg (Immediate-release) per tablet. It belongs to the Biguanide + DPP-4 inhibitor + SGLT2 inhibitor class of medicines.

Uses of Istamet D Ir 5/50/1000

Type 2 diabetes mellitus: to improve glycaemic control as an adjunct to diet and exercise when treatment with these medicines is appropriate.

Key benefits

• Helps reduce fasting and post-meal blood sugar
• Improves insulin sensitivity and lowers glucose production
• Promotes glucose removal via urine
• Low risk of hypoglycaemia when used without insulin/secretagogues
• May support weight and blood pressure reduction due to SGLT2 action

How Istamet D Ir 5/50/1000 works

Metformin decreases hepatic glucose production and improves insulin sensitivity. Sitagliptin (a DPP-4 inhibitor) increases incretin levels, enhancing glucose-dependent insulin release and reducing glucagon. Dapagliflozin (an SGLT2 inhibitor) increases urinary glucose excretion by blocking glucose reabsorption in the kidney.

How to take Istamet D Ir 5/50/1000

Oral tablet (IR). Take as prescribed by your doctor, usually with meals to reduce stomach upset. Swallow whole with water; do not crush/chew. Maintain adequate hydration; follow diet/exercise advice and monitor blood glucose.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause dehydration and a fall in blood pressure. It may cause low blood sugar, particularly if you also take other diabetes medicines. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Istamet D Ir 5/50/1000

Most side effects of Istamet D Ir 5/50/1000 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhoea
• abdominal pain
• loss of appetite
• headache
• upper respiratory tract infection
• nasopharyngitis
• urinary tract infection
• genital fungal infection
• increased urination
• dizziness

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Istamet D Ir 5/50/1000

Warnings and precautions

Prescription-only antidiabetic. Risk of lactic acidosis with metformin (higher in kidney/liver impairment, dehydration, heavy alcohol use, severe infection, hypoxia); stop and seek care if unexplained tiredness, muscle pain, fast breathing, abdominal pain occur. Dapagliflozin may cause dehydration/low blood pressure, genital infections, UTI, ketoacidosis (can occur with normal sugars), and rare Fournier’s gangrene—seek urgent help for severe nausea/vomiting, abdominal pain, rapid breathing, genital/perineal pain/swelling/fever. Sitagliptin: rare pancreatitis and hypersensitivity. Monitor kidney function; dose/therapy adjustments may be needed in renal impairment. Temporarily withhold around major surgery/acute illness and before iodinated contrast as advised by doctor. Not for type 1 diabetes or diabetic ketoacidosis.

Do not take Istamet D Ir 5/50/1000 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Insulin/sulfonylureas (increased hypoglycaemia risk),diuretics and antihypertensives (increased dehydration/hypotension),alcohol (increases lactic acidosis risk),iodinated contrast media (risk of lactic acidosis—temporary stoppage of metformin),cimetidine (may increase metformin levels),digoxin (sitagliptin may increase digoxin levels),carbonic anhydrase inhibitors e.g. topiramate/acetazolamide (increased acidosis risk),NSAIDs/ACE inhibitors/ARBs (may affect kidney function—monitor),other SGLT2 inhibitors or DPP-4 inhibitors (duplicate therapy)

How to store Istamet D Ir 5/50/1000

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep out of reach of children.

Expert advice for Istamet D Ir 5/50/1000

Take it in the morning so the extra urine does not disturb your sleep. Keep up your fluid intake and maintain genital hygiene. Tell any doctor treating you for an acute illness that you take this medicine. It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

SUN PHARMA

Therapeutic class:

Antidiabetic

Drug class:

Biguanide + DPP-4 inhibitor + SGLT2 inhibitor