Prescription requiredCardiovascular (Heart failure/Antihypertensive)

Sacustart 50 Tab — Side Effects & Warnings

Known side effects of Sacustart 50 Tab include Low blood pressure (dizziness),increased potassium (hyperkalemia),kidney function changes,headache,cough,nausea,diarrhea,fatigue. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Low blood pressure (dizziness)
increased potassium (hyperkalemia)
kidney function changes
headache
cough
nausea
diarrhea
fatigue

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Prescription-only. Risk of angioedema (higher in patients with prior ACEi-related angioedema); stop and seek urgent care if face/lip/tongue swelling or breathing difficulty occurs. Contraindicated in pregnancy; can cause fetal harm. Avoid use with ACE inhibitors (need 36-hour gap) and avoid in patients with history of angioedema related to ACEi/ARB. Use with caution in renal impairment, liver impairment, low blood pressure, dehydration, and in patients with high potassium; periodic monitoring of BP, kidney function and serum potassium is recommended.

Drug Interactions

Sacustart 50 Tab may interact with the following:

ACE inhibitors (contraindicated; 36-hour washout required)
aliskiren (avoid in diabetes; caution in renal impairment)
potassium supplements/potassium-sparing diuretics (e.g.
spironolactone
eplerenone
amiloride)
NSAIDs (may worsen kidney function)
lithium (may increase lithium levels/toxicity)
other antihypertensives (additive hypotension)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Not recommended (contraindicated in pregnancy)

Alcohol Interaction

Use with caution (may increase dizziness/low blood pressure)

Habit Forming

Storage

Store below 25°C in a cool, dry place. Protect from moisture and light; keep in original pack and out of reach of children.

Sacustart 50 Tab — Safety Summary

Composition: Sacubitril 24 mg + Valsartan 26 mg (as Sacubitril/Valsartan) per tablet
Prescription: Required (Rx)
Pregnancy: Not recommended (contraindicated in pregnancy)
Alcohol: Use with caution (may increase dizziness/low blood pressure)
Habit forming: No

Sacustart 50 Tab — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.