Prescription requiredCardiovascular (Heart failure/Antihypertensive)

Sacustart 50 Tab — Uses, Dosage & Benefits

Sacustart 50 Tab is used for Treatment of chronic heart failure (HFrEF) to reduce risk of cardiovascular death and hospitalization; used as a replacement for ACE inhibitor/ARB in suitable patients.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

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Active Ingredient / Composition

Sacubitril 24 mg + Valsartan 26 mg (as Sacubitril/Valsartan) per tablet

What is Sacustart 50 Tab used for?

Treatment of chronic heart failure (HFrEF) to reduce risk of cardiovascular death and hospitalization; used as a replacement for ACE inhibitor/ARB in suitable patients

How Sacustart 50 Tab Works

Sacubitril inhibits neprilysin, increasing levels of natriuretic peptides that promote vasodilation and diuresis. Valsartan blocks angiotensin II (AT1) receptors, reducing vasoconstriction and aldosterone effects. Together they lower cardiac workload and improve heart failure outcomes.

Dosage & Directions

Oral tablet. Take exactly as prescribed, usually twice daily, with or without food, at the same times each day. Do not take with an ACE inhibitor; allow a 36-hour washout when switching from an ACE inhibitor to sacubitril/valsartan.

Always follow your doctor's prescription. Do not self-medicate.

Key Benefits

Reduces risk of heart failure hospitalization
Reduces cardiovascular death risk
Improves symptoms and exercise tolerance in HFrEF
Lowers blood pressure and cardiac workload

Pregnancy

Not recommended (contraindicated in pregnancy)

Alcohol Interaction

Use with caution (may increase dizziness/low blood pressure)

Sacustart 50 Tab — Quick Facts

Composition: Sacubitril 24 mg + Valsartan 26 mg (as Sacubitril/Valsartan) per tablet
Therapeutic class: Cardiovascular (Heart failure/Antihypertensive)
Drug class: Angiotensin receptor neprilysin inhibitor (ARNI)
Prescription: Required (Rx)
Price: ₹196
Habit forming: No
Storage: Store below 25°C in a cool, dry place. Protect from moisture and light; keep in original pack and out of reach of children.

Sacustart 50 Tab — Usage FAQs

How should I take this medicine?

Follow the dosage prescribed by your doctor. Do not alter the dose without medical advice.

Can I take this medicine without a prescription?

Prescription-required medicines need a valid Rx. OTC medicines can be purchased directly.

What if I miss a dose?

Take the missed dose as soon as you remember, unless it is close to your next scheduled dose. Do not double the dose.

How long does it take to show effect?

The time to show effect varies by medicine and condition. Consult your doctor for specific timelines.

Sacustart 50 Tab — Uses, Dosage & Benefits

Active Ingredient / Composition

What is Sacustart 50 Tab used for?

How Sacustart 50 Tab Works

Dosage & Directions

Key Benefits

Pregnancy

Alcohol Interaction

Sacustart 50 Tab — Quick Facts

Sacustart 50 Tab — Usage FAQs

More from PingMeDoc™

Safety disclaimer

Sacustart 50 Tab — Uses, Dosage & Benefits

Active Ingredient / Composition

What is Sacustart 50 Tab used for?

How Sacustart 50 Tab Works

Dosage & Directions

Key Benefits

Pregnancy

Alcohol Interaction

Sacustart 50 Tab — Quick Facts

Sacustart 50 Tab — Usage FAQs

More from PingMeDoc™

Safety disclaimer