ZIPANT -D SR

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Gastroesophageal reflux disease (GERD), heartburn and acid reflux, gastritis and acid-peptic disorders, nausea/vomiting associated with reflux or delayed gastric emptying

Pantoprazole is a proton pump inhibitor that reduces stomach acid by blocking the H+/K+ ATPase pump in gastric parietal cells. Domperidone is a peripheral dopamine (D2) antagonist that increases gastric motility and helps relieve nausea by enhancing gastric emptying.

Take as directed by doctor. Usually 1 capsule once daily, preferably 30 minutes before breakfast; swallow whole and do not crush/chew (SR/enteric-coated).

Headache, diarrhoea, abdominal pain, nausea, dry mouth, dizziness, constipation, flatulence

Use with caution in liver disease. Domperidone may increase risk of QT prolongation/serious arrhythmias—avoid in patients with known QT prolongation, significant electrolyte disturbances, or underlying cardiac disease; do not exceed prescribed dose. Long-term PPI use may be associated with low magnesium/vitamin B12, bone fracture risk, and C. difficile-associated diarrhoea; report persistent diarrhoea. Seek medical advice if alarm symptoms occur (weight loss, vomiting blood, black stools, difficulty swallowing).

QT-prolonging drugs (e.g., amiodarone, sotalol, certain antipsychotics), strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin/clarithromycin, ritonavir) increase domperidone levels; drugs needing acidic pH for absorption (e.g., ketoconazole, atazanavir), warfarin (monitor), methotrexate (high-dose), digoxin