Zolfresh 10 Tablet

Drug | Tablet

Short-term treatment of insomnia, particularly difficulty in falling asleep (sleep-onset insomnia) and sometimes frequent night awakenings

Zolpidem is a non-benzodiazepine hypnotic (Z-drug) that enhances the effect of GABA at the GABA-A receptor (preferentially via the BZ1/omega-1 site). This reduces neuronal activity in the brain, helping induce sleep.

Take exactly as prescribed, usually 1 tablet (10 mg) once daily at bedtime, immediately before sleep. Take on an empty stomach or after a light meal (food can delay onset). Ensure 7–8 hours available for sleep; swallow whole with water; do not take a second dose the same night.

Drowsiness, dizziness, headache, nausea, diarrhea, fatigue, next-day sleepiness, memory impairment, abnormal dreams, sleepwalking/complex sleep behaviors

Prescription-only sleep medicine. May cause next-day impairment—avoid driving/operating machinery until you know its effects. Risk of dependence, misuse and withdrawal; use the lowest effective dose for the shortest duration. Can cause complex sleep behaviors (sleepwalking, sleep-driving); stop and seek medical advice if these occur. Avoid in severe liver impairment; use lower dose in elderly, debilitated patients, or mild–moderate hepatic impairment. Use caution in depression, history of substance use disorder, respiratory disease (sleep apnea/COPD), and in combination with other CNS depressants. Not recommended in children.

Alcohol and other CNS depressants (benzodiazepines, opioids, sedating antihistamines, antipsychotics) increase sedation/respiratory depression; CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, ritonavir) may increase levels; CYP3A4 inducers (rifampicin, carbamazepine, phenytoin, St John’s wort) may reduce effect; caution with SSRIs/SNRIs and other sedatives; opioids increase risk of profound sedation and breathing problems

Store below 25°C in a cool, dry place away from moisture and light. Keep out of reach of children.

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