Startglim M1 Tablet

Composition of Startglim M1 Tablet

Startglim M1 Tablet contains Glimepiride 1 mg + Metformin Hydrochloride 500 mg (sustained/extended release). It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Startglim M1 Tablet

Type 2 diabetes mellitus in adults when diet and exercise alone or monotherapy is insufficient; helps control blood glucose levels.

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin sensitivity
• Supports long-term glycaemic control (HbA1c)
• Helps reduce diabetes-related complications with good control

How Startglim M1 Tablet works

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves peripheral glucose utilization. Metformin reduces glucose production by the liver and improves insulin sensitivity, lowering blood sugar without usually causing hypoglycaemia when used alone.

How to take Startglim M1 Tablet

Oral tablet. Take exactly as prescribed, usually once daily with or immediately after food (preferably breakfast) to reduce stomach upset. Swallow whole if SR/ER; do not crush or chew. Monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Startglim M1 Tablet

Most side effects of Startglim M1 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• headache
• dizziness
• weight gain

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Startglim M1 Tablet

Warnings and precautions

Risk of hypoglycaemia (higher with missed meals, excess exercise, alcohol, or other antidiabetics); avoid skipping meals. Metformin may rarely cause lactic acidosis—seek urgent care for rapid breathing, severe weakness, muscle pain, unusual sleepiness, or stomach pain; risk increases with kidney or liver impairment, dehydration, severe infection, or heavy alcohol use. Use with caution in elderly and in renal impairment; kidney function should be assessed before and during treatment. Withhold metformin temporarily before/after iodinated contrast imaging and major surgery as advised by doctor. Not for type 1 diabetes or diabetic ketoacidosis.

Do not take Startglim M1 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Insulin/other antidiabetics (increased hypoglycaemia), alcohol (increased hypoglycaemia/lactic acidosis risk), corticosteroids and thiazide diuretics (raise glucose), beta-blockers (mask hypoglycaemia symptoms), ACE inhibitors (may increase hypoglycaemia), fluconazole and other CYP2C9 inhibitors (increase glimepiride effect), rifampicin (reduce glimepiride effect), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (increase metformin levels)

How to store Startglim M1 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Expert advice for Startglim M1 Tablet

Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

SANZ PHARMACEUTICALS

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide