Maxgalin Nt

Pregabalin 75 mg + Nortriptyline 10 mg (tablet/capsule; strength may vary by variant)

Neuropathic (nerve) pain such as diabetic peripheral neuropathy, post-herpetic neuralgia, sciatica/radiculopathy, nerve pain associated with spinal disorders; used when pain has burning, tingling, shooting or numbness features

Pregabalin reduces release of pain-signalling neurotransmitters by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the CNS. Nortriptyline (a tricyclic antidepressant) increases norepinephrine/serotonin activity in pain pathways and modulates pain perception, providing additive relief in neuropathic pain.

Take orally exactly as prescribed, usually once daily at night or as directed; swallow whole with water. Can be taken with or without food; taking at bedtime may reduce daytime drowsiness. Do not stop suddenly—dose should be tapered on medical advice.

Dizziness, drowsiness/sedation, dry mouth, constipation, blurred vision, weight gain, swelling of feet/ankles (edema), headache, difficulty concentrating

May cause dizziness and sleepiness—avoid driving/operating machinery until effects are known. Use caution in elderly, kidney disease (dose adjustment may be needed for pregabalin), glaucoma, prostate enlargement/urinary retention, heart disease/arrhythmias, and history of seizures. Do not stop abruptly (withdrawal symptoms possible). Monitor for mood changes or suicidal thoughts. Risk of additive CNS depression with alcohol/sedatives.

Alcohol, opioids (e.g., tramadol, morphine), benzodiazepines and other sedatives (increased drowsiness/respiratory depression); other antidepressants/MAO inhibitors (serotonin syndrome/raised adverse effects—avoid MAOIs); anticholinergics (worsened dry mouth/constipation/urinary retention); antihypertensives (may increase dizziness); medicines that prolong QT (caution with nortriptyline)

Store below 25°C in a dry place, protected from moisture and light. Keep out of reach of children.

Pregalin NT 75/10 Tablet, Nervup NT 75/10 Tablet, Pregaba NT 75/10 Tablet, Pregabid NT 75/10 Tablet, Maxgalin NT (other strength variants)