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SUN PHARMA
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Important advisories specific to this medicine.
Pregnancy
Use with caution / Consult doctor (use only if benefits outweigh risks; newborn may have withdrawal/EPS if exposed late in pregnancy)
Alcohol
Avoid
Treatment of schizophrenia in adults; may be used for maintenance therapy with a long-acting antipsychotic as prescribed.
Injection site pain, sleepiness/sedation, dizziness, headache, weight gain, increased prolactin (breast changes/menstrual changes), restlessness/akathisia, tremor/extrapyramidal symptoms, constipation, dry mouth, nausea
Paliperidone is an atypical antipsychotic that mainly blocks dopamine (D2) and serotonin (5‑HT2A) receptors, helping reduce psychotic symptoms. The palmitate ester is a long‑acting depot form that slowly releases paliperidone after intramuscular injection for sustained effect.
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SUN PHARMA
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Manufacturer: SUN PHARMA
Disclaimer: Product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalised guidance.
Sources: Manufacturer labeling/pack insert, established medical literature on paliperidone palmitate, standard psychiatric treatment guidelines
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Treatment of schizophrenia in adults; may be used for maintenance therapy with a long-acting antipsychotic as prescribed.
Paliperidone is an atypical antipsychotic that mainly blocks dopamine (D2) and serotonin (5‑HT2A) receptors, helping reduce psychotic symptoms. The palmitate ester is a long‑acting depot form that slowly releases paliperidone after intramuscular injection for sustained effect.
Prescription-only long-acting injection. Administer as an intramuscular injection by a healthcare professional (deltoid or gluteal muscle as advised). Follow the exact dosing schedule set by the psychiatrist; do not self-inject, shake, or mix unless instructed in the product leaflet.
Injection site pain, sleepiness/sedation, dizziness, headache, weight gain, increased prolactin (breast changes/menstrual changes), restlessness/akathisia, tremor/extrapyramidal symptoms, constipation, dry mouth, nausea
Use only under specialist supervision. May cause drowsiness and dizziness—avoid driving until you know the effect. Risk of extrapyramidal symptoms/tardive dyskinesia, neuroleptic malignant syndrome, increased prolactin, weight gain and metabolic changes (blood sugar/lipids), orthostatic hypotension, seizures, QT prolongation/heart rhythm problems. Increased risk of stroke and death in elderly patients with dementia-related psychosis (not approved). Use caution in diabetes, obesity, Parkinsonism, epilepsy, cardiovascular disease, and in patients with history of blood clots. Monitor weight, glucose, lipids, and movement disorders as advised.
Alcohol and other CNS depressants (increased sedation), medicines that prolong QT (e.g., amiodarone, sotalol, certain macrolides/fluoroquinolones, some antidepressants/antipsychotics), antihypertensives (additive low BP), dopamine agonists (e.g., levodopa, bromocriptine) may reduce effect, strong CYP inducers (e.g., carbamazepine, rifampicin) may reduce paliperidone exposure, valproate may increase paliperidone levels
Store refrigerated at 2–8°C; do not freeze. Keep in original pack protected from light. Do not use if suspension shows clumping that does not disperse on gentle shaking as per leaflet; keep out of reach of children.
Invega Sustenna 50 mg Injection, Paliperidone Palmitate 50 mg LA Injection (generic equivalents), Risperidone long-acting injection (Risperdal Consta)
Prescription-only long-acting injection. Administer as an intramuscular injection by a healthcare professional (deltoid or gluteal muscle as advised). Follow the exact dosing schedule set by the psychiatrist; do not self-inject, shake, or mix unless instructed in the product leaflet.
Store refrigerated at 2–8°C; do not freeze. Keep in original pack protected from light. Do not use if suspension shows clumping that does not disperse on gentle shaking as per leaflet; keep out of reach of children.
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