Zita-Met 20/500 mg Tablet

Composition of Zita-Met 20/500 mg Tablet

Zita-Met 20/500 mg Tablet contains Teneligliptin 20 mg + Metformin Hydrochloride 500 mg (usually as sustained/extended release; verify pack). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Zita-Met 20/500 mg Tablet

• Type 2 diabetes mellitus to improve blood glucose control in adults
• as an adjunct to diet and exercise; used when metformin alone is inadequate or when switching to combination therapy.

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves HbA1c control
• Weight-neutral/less weight gain than some alternatives
• Low risk of hypoglycaemia when used without insulin/sulfonylureas

How Zita-Met 20/500 mg Tablet works

Teneligliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), enhancing glucose-dependent insulin release and reducing glucagon secretion. Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity, lowering fasting and post-meal glucose.

How to take Zita-Met 20/500 mg Tablet

Oral tablet. Take exactly as prescribed, usually once daily with food (preferably with the main meal) to reduce stomach upset. Swallow whole if SR/ER; do not crush or chew. Monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zita-Met 20/500 mg as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zita-Met 20/500 mg than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zita-Met 20/500 mg Tablet

Most side effects of Zita-Met 20/500 mg are mild and settle as the body adjusts. Reported side effects include:

• nausea
• vomiting
• diarrhea
• abdominal discomfort
• loss of appetite
• headache
• dizziness
• nasopharyngitis
• hypoglycaemia (especially with insulin/sulfonylureas)
• taste disturbance

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zita-Met 20/500 mg Tablet

Warnings and precautions

Not for type 1 diabetes or diabetic ketoacidosis. Risk of lactic acidosis with metformin—seek urgent care for rapid breathing, severe weakness, abdominal pain, or unusual sleepiness; higher risk with kidney impairment, dehydration, severe infection, alcohol use, liver disease, or heart failure. Check renal function before and during therapy; dose adjustment/avoid in significant renal impairment. Temporarily stop metformin around iodinated contrast procedures and major surgery as advised by doctor. Monitor for pancreatitis (severe abdominal pain), hypersensitivity reactions, and vitamin B12 deficiency with long-term use.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), insulin and sulfonylureas (increased hypoglycaemia risk), iodinated contrast media (renal risk/lactic acidosis—hold metformin), carbonic anhydrase inhibitors such as topiramate/acetazolamide (metabolic acidosis risk), cimetidine (may increase metformin levels), corticosteroids/thiazide diuretics/sympathomimetics (may raise glucose), ACE inhibitors (may enhance glucose-lowering), strong CYP/P-gp modulators may affect teneligliptin exposure (clinical relevance varies).

How to store Zita-Met 20/500 mg Tablet

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Manufacturer and class

Manufacturer:

GLENMARK PHARMACEUTICALS

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide