Zitamet 20/1000 Tablet

Composition of Zitamet 20/1000 Tablet

Zitamet 20/1000 Tablet contains Teneligliptin 20 mg + Metformin Hydrochloride 1000 mg (Prolonged/Extended Release, if specified on pack). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Zitamet 20/1000 Tablet

• Type 2 diabetes mellitus to improve blood glucose control along with diet and exercise
• especially when control is inadequate with metformin alone or combination therapy is required

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves HbA1c control
• Low risk of hypoglycaemia when used without insulin/sulfonylurea
• Metformin helps improve insulin sensitivity and may support weight neutrality

How Zitamet 20/1000 Tablet works

Teneligliptin is a DPP-4 inhibitor that increases incretin levels (GLP-1, GIP), thereby increasing insulin release and decreasing glucagon in a glucose-dependent manner. Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity, reducing blood glucose levels.

How to take Zitamet 20/1000 Tablet

Take by mouth exactly as prescribed. Usually taken once daily with food (preferably with evening meal) to reduce stomach upset; if it is an extended-release tablet, swallow whole—do not crush/chew/split. Monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zitamet 20/1000 as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zitamet 20/1000 than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zitamet 20/1000 Tablet

Most side effects of Zitamet 20/1000 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal discomfort
• loss of appetite
• headache
• dizziness
• nasopharyngitis
• hypoglycaemia (especially with insulin/sulfonylureas)
• taste disturbance

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zitamet 20/1000 Tablet

Warnings and precautions

Prescription-only antidiabetic. Metformin may rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, alcohol use, heart/liver failure; assess renal function before and during therapy. Avoid/use with caution in severe renal impairment; temporarily stop around iodinated contrast procedures and major surgery as advised. DPP-4 inhibitors can rarely cause pancreatitis or severe joint pain; seek medical help for severe abdominal pain. Not for type 1 diabetes or diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media (risk of renal decline/lactic acidosis), carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cimetidine (may increase metformin levels), insulin/sulfonylureas (increased hypoglycaemia risk), diuretics/ACE inhibitors/NSAIDs (may affect renal function), corticosteroids and sympathomimetics (may raise glucose)

How to store Zitamet 20/1000 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Manufacturer and class

Manufacturer:

GLENMARK PHARMACEUTICALS

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide