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Tablet · 1000 mg · 10`S
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Divalproex (1000mg)
Valkem Od 1000 mg Tablet contains Divalproex (1000mg) and is used for epilepsy/seizure disorders (generalised and partial seizures). Prescription required.
Monograph
Valkem OD 1000 mg Tablet is a prescription medicine containing Divalproex (1000mg). It is used for epilepsy, seizure disorders (generalised, partial seizures), management of bipolar disorder (acute mania, maintenance) as prescribed and prevention of migraine (when prescribed). It belongs to the group of medicines called Anticonvulsant (valproate; GABA enhancer).
Tablet (OD/prolonged-release): take exactly as prescribed, usually once daily at the same time. The dose and how long you take it depend on what you are being treated for and how you respond. Do not take more, or for longer, than your doctor has advised.
The side effects seen most often with Valkem OD 1000 mg Tablet are nausea, vomiting, stomach pain and diarrhoea. Most are mild and settle as the body gets used to the medicine. Tell your doctor if one persists or worries you.
Before you start, tell your doctor about any liver, kidney or heart problem, whether you are pregnant, planning a pregnancy or breastfeeding, and every other medicine you take, including supplements and ayurvedic preparations. Some of them can change how Valkem OD 1000 mg Tablet works.
Most side effects of Valkem OD are mild and settle as the body gets used to the medicine. The ones reported most often are:
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Tablet (OD/prolonged-release): take exactly as prescribed, usually once daily at the same time. Swallow whole with water; do not crush/chew/split prolonged-release tablets. Preferably take with food to reduce stomach upset.
Valproate increases the levels of the inhibitory neurotransmitter GABA and also modulates sodium and calcium channels in the brain. This stabilizes neuronal firing and helps prevent seizures and mood swings.
Prescription-only medicine. Risk of serious liver injury (especially in first 6 months), pancreatitis, and hyperammonaemia—seek urgent care for severe abdominal pain, persistent vomiting, jaundice, confusion, unusual bruising/bleeding. May cause drowsiness—avoid driving if affected. Monitor liver function tests, platelet count and valproate levels as advised. Use caution in patients with liver disease, bleeding disorders, mitochondrial disorders (POLG), and in children. Do not stop abruptly without medical advice.
If you miss a dose of Valkem OD 1000mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause deep unconsciousness, slowed breathing and dangerous heart rhythm disturbance. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Alcohol (additive sedation), lamotrigine (increases lamotrigine levels/risk of rash), carbamazepine/phenytoin/phenobarbital (altered levels), topiramate (risk of hyperammonaemia/encephalopathy), aspirin/NSAIDs and warfarin (increased bleeding risk), rifampicin (reduced valproate levels), antidepressants/benzodiazepines (additive CNS depression)
Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.
Valparin Chrono 1000 Tablet, Encorate Chrono 1000 Tablet, Divalproex ER 1000 Tablet, Valprol CR 1000 Tablet, Valcivir-CR/Valproate CR 1000 Tablet
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.
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Medical disclaimer: product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalised guidance.
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