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Laboratory test

Sm (Smith) Antibody IgG Test

Explore the SM (Smith) Antibody, IgG test at PingMeDoc™ for the specified laboratory investigation. Check the exact measurements, specimen type, preparation instructions, current price and report turnaround shown in the laboratory catalogue. Ask a doctor whether this test is appropriate for your symptoms or monitoring needs.

Also known as

Anti-Smith Antibody IgG Test · Smith IgG Antibody · Anti-Sm Antibody · Anti Smith Antibody · Sm Antibody

Sample
Blood
Fasting
Not required
Expected report time
24–48 hours
Parameters
1

Anti-Smith Antibody IgG Test: quick answers

Anti-Smith Antibody IgG Test price
₹1,120, home sample collection
Done for
Suspected systemic lupus erythematosus (SLE) after a positive ANA; Joint pain, rash, mouth ulcers or unexplained fever with a positive ANA; Part of an extractable nuclear antigen (ENA) panel
Fasting
Not required
Report
24–48 hours

What is the Anti-Smith Antibody IgG Test?

The anti-Smith (anti-Sm) IgG test looks for antibodies against the Smith antigen, a protein found in the cell nucleus. A positive result is highly specific for systemic lupus erythematosus (SLE), but only a minority of people with lupus have it, so a negative result does not rule lupus out.

What your Anti-Smith Antibody IgG Test result means

Positive
Strongly supports SLE, and anti-Smith is one of the immunological criteria in the 2019 EULAR/ACR classification criteria. A rheumatologist makes the diagnosis from symptoms and other tests.
Negative
Common in SLE, since only a fraction of patients carry anti-Sm antibodies. Other tests such as anti-dsDNA and complement levels are used.
Borderline
Usually repeated, and read against the ANA result and the clinical picture.

One result is not a diagnosis. A doctor reads it with your symptoms, history, medicines and other tests.

Why is the Anti-Smith Antibody IgG Test done?

  • Suspected systemic lupus erythematosus (SLE) after a positive ANA
  • Joint pain, rash, mouth ulcers or unexplained fever with a positive ANA
  • Part of an extractable nuclear antigen (ENA) panel
  • Supporting a lupus diagnosis when other tests are unclear

What does the Sm (Smith) Antibody IgG Test measure?

1 parameter. Expand a group to see the measurements, units and available method details.

Other measurements1 parameter
ParameterUnit
Anti-Sm (Smith) Antibody, IgGAU/mL

The reference interval printed on your actual laboratory report governs interpretation. Intervals can vary by laboratory, method, age, sex and pregnancy. Methods can also vary by processing laboratory.

Anti-Smith Antibody IgG Test: sample & preparation

Sample: Blood. Fasting: Not required.

  • You do not need to fast for this blood test. This test is usually ordered together with ANA and other autoantibody tests to evaluate suspected systemic lupus erythematosus.

Frequently asked questions

What is the Smith IgG antibody test?
It checks the blood for IgG antibodies directed at the Smith antigen. It is one of the most specific blood tests for lupus.
Does a positive anti-Smith antibody mean I have lupus?
It strongly points that way, because the antibody is rarely found in other conditions. Lupus is still diagnosed by a doctor using symptoms, examination and several tests, not this antibody alone.
Can I have lupus with a negative anti-Smith result?
Yes. Most people with lupus are negative for anti-Smith, so a negative result does not exclude it.
How is anti-Smith different from ANA and anti-dsDNA?
ANA is a sensitive screening test that is positive in many conditions. Anti-Smith and anti-dsDNA are more specific tests used after a positive ANA to support lupus.
Do I need to fast for an anti-Smith test?
No fasting is needed. Tell the doctor about any medicines you take, as some drugs can cause lupus-like antibody changes.
How much does the SM (Smith) Antibody, IgG cost?
The current online price is ₹1,120. Review your booking total before payment.
Can I book this test for home collection?
Yes. Add your collection address and choose an available collection slot at checkout.
When is the report expected?
The catalogue lists 24–48 hours. Confirm the collection and report schedule with the booking team.
Can I book this with other tests?
You can add available tests to the same cart. Review the combined preparation instructions and collection requirements with the booking team.

Sources: Aringer M et al. 2019 EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus. Arthritis Rheumatol 2019; Fanouriakis A et al. EULAR recommendations for the management of systemic lupus erythematosus: 2023 update. Ann Rheum Dis 2024; Tietz Textbook of Laboratory Medicine, autoantibodies in systemic autoimmune disease. General information, not medical advice.

This page gives catalogue facts only (sample, preparation, report time) and has not been reviewed by a doctor. It is general information, not a diagnosis or advice for you: your doctor decides which tests you need and what the results mean.

Book the Sm (Smith) Antibody IgG Test

1 parameter · No fasting required · Report time: 24–48 hours

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₹1,120
₹1,120

Test price