Zonalta 8 mg Tablet

Composition of Zonalta 8 mg Tablet

Zonalta 8 mg Tablet contains Endoxifen (8mg). It belongs to the 5-HT3 receptor antagonist (serotonin antagonist) class of medicines.

Uses of Zonalta 8 mg Tablet

• Prevention and treatment of nausea and vomiting due to chemotherapy (CINV)
• radiotherapy (RINV)
• and postoperative nausea and vomiting (PONV)

Key benefits

• Prevents chemotherapy-induced nausea and vomiting
• Prevents radiotherapy-related nausea and vomiting
• Helps control postoperative nausea and vomiting
• Improves tolerance to cancer therapy

How Zonalta 8 mg Tablet works

Ondansetron is a selective 5-HT3 (serotonin) receptor antagonist. It blocks serotonin-mediated stimulation of vagal afferents in the gut and the chemoreceptor trigger zone in the brain, thereby reducing nausea and vomiting.

How to take Zonalta 8 mg Tablet

Take tablet by mouth exactly as prescribed. It may be taken with or without food; taking after food may reduce stomach upset. Typical use is before chemotherapy/radiotherapy or as directed for postoperative nausea; swallow with water.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Zonalta 8mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

Taking more Zonalta than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zonalta 8 mg Tablet

Most side effects of Zonalta are mild and settle as the body adjusts. Reported side effects include:

• Headache
• constipation
• diarrhea
• dizziness
• fatigue
• flushing

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zonalta 8 mg Tablet

Warnings and precautions

Use with caution in patients with prolonged QT interval, heart rhythm disorders, electrolyte imbalance (low potassium/magnesium), heart failure, or severe liver impairment (dose adjustment may be needed). Seek urgent help for palpitations, fainting, severe dizziness, or signs of serotonin syndrome (agitation, sweating, tremor) especially if taken with serotonergic medicines. Not recommended with apomorphine (risk of severe hypotension and loss of consciousness).

Interactions with other medicines

Apomorphine (contraindicated), other QT-prolonging drugs (e.g., amiodarone, sotalol, quinolones, macrolides, antipsychotics), serotonergic drugs (SSRIs/SNRIs, MAOIs, tramadol, linezolid) increased serotonin syndrome risk, CYP3A4 inducers (carbamazepine, phenytoin, rifampicin) may reduce effect

How to store Zonalta 8 mg Tablet

Store below 25°C in a dry place. Protect from moisture and light. Keep out of reach of children.

Expert advice for Zonalta 8 mg Tablet

Inform your doctor if you experience chest pain or a fast heartbeat after starting treatment with Zonalta 8mg Tablet. Avoid breastfeeding during treatment with this medicine and for three months after the last dose. Zonalta 8mg Tablet might cause menstrual irregularity or amenorrhea. Consult your doctor. Use contraception to avoid getting pregnant during treatment with this medicine since it may cause fetal harm.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antiemetic

Drug class:

5-HT3 receptor antagonist (serotonin antagonist)

Chemical class:

Triphenylethylenes