A-Tret 25 mg Capsule

A-Tret 25 mg Capsule contains Tretinoin (All-trans retinoic acid) 25 mg capsule. Prescription required.

Treatment of acute promyelocytic leukemia (APL, M3 subtype) in patients with t(15;17) / PML-RARA, typically for induction of remission under specialist supervision

Tretinoin is a retinoid that binds to retinoic acid receptors and promotes differentiation and maturation of malignant promyelocytes. In APL it helps overcome the differentiation block caused by the PML-RARA fusion, reducing abnormal blasts and helping restore normal blood cell development.

Oral capsule. Dose and duration are strictly as prescribed by an oncologist (commonly weight-based in APL). Swallow whole with water, preferably with food to improve absorption; take at the same times each day. Do not crush or open the capsule.

Headache, fever, skin rash, dry skin/lips, nausea, vomiting, diarrhea, abdominal pain, bone/joint pain, fatigue, peripheral edema, elevated liver enzymes, increased blood lipids

For use only under specialist (oncology/hematology) supervision. Risk of ATRA (differentiation) syndrome/retinoic acid syndrome (fever, breathing difficulty, weight gain, edema, low blood pressure) which can be life-threatening—seek urgent care. Highly teratogenic: strict pregnancy prevention required; avoid in pregnancy and do not breastfeed. Monitor CBC, liver function, lipids, and for blood clots; caution in hepatic impairment, hyperlipidemia, and pancreatitis risk. May cause dizziness/visual disturbances—use caution while driving. Avoid vitamin A supplements to reduce toxicity.

Tetracyclines (risk of increased intracranial pressure), vitamin A/other retinoids (additive toxicity), azole antifungals (e.g., ketoconazole/itraconazole) and macrolides (may increase levels), CYP inducers (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital) may reduce effect, drugs increasing thrombotic risk (e.g., hormonal contraceptives)

Store below 25°C, protected from light and moisture. Keep in original blister pack. Keep out of reach of children.

Vesanoid 10mg Capsule, Tretin 10mg Capsule, Tretinoin 10mg Capsule (generic), ATRA 10mg Capsule, Tretinoin (All-trans retinoic acid) capsules (other brands)