Distributor inventory | Tablet

Type 2 diabetes mellitus: adjunct to diet and exercise to improve glycaemic control in adults when dual therapy is appropriate (including patients inadequately controlled on either component).

Empagliflozin is an SGLT2 inhibitor that lowers blood sugar by increasing urinary glucose excretion via the kidneys. Linagliptin is a DPP-4 inhibitor that increases incretin hormones, enhancing insulin release and reducing glucagon secretion in a glucose-dependent manner.

Oral tablet. Usually taken once daily, with or without food, at the same time each day. Swallow whole with water; do not crush unless advised. Dose and duration as prescribed by a doctor; continue diet/exercise and regular glucose monitoring.

Increased urination, thirst, genital fungal infection, urinary tract infection, nasopharyngitis, headache, dizziness, nausea, rash, hypoglycaemia (especially with insulin/sulfonylurea)

Not for type 1 diabetes or diabetic ketoacidosis. Risk of dehydration/low blood pressure and acute kidney injury—maintain fluids; caution in elderly, diuretics, low BP, kidney disease. May increase risk of genital mycotic infections and UTIs; seek care for fever, flank pain, painful urination. Stop and seek urgent care if symptoms of ketoacidosis occur (nausea/vomiting, abdominal pain, rapid breathing) even if sugars are not very high. Rare risk of pancreatitis (persistent severe abdominal pain) and hypersensitivity with linagliptin. Temporarily withhold before major surgery/serious illness or prolonged fasting as advised. Kidney function should be assessed before and during therapy; not recommended in severe renal impairment/ESRD.

Insulin and sulfonylureas (increased hypoglycaemia risk), diuretics (increased dehydration/hypotension risk), lithium (possible level changes with SGLT2 inhibitors), strong CYP3A4/P-gp inducers e.g., rifampicin, carbamazepine, phenytoin, phenobarbital, St John’s wort (may reduce linagliptin effect)

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Glyxambi 25/5 Tablet, Jardiance Duo 25/5 Tablet, Empagliflozin 25 mg + Linagliptin 5 mg Tablets (generic equivalents), EmpaLin 25/5 Tablet, EmpaLina 25/5 Tablet