Celavi M 10/25MG Tab

Tablet

Type 2 diabetes mellitus: adjunct to diet and exercise to improve glycaemic control; may be used when dual therapy is needed (SGLT2 inhibitor + DPP-4 inhibitor).

Empagliflozin (SGLT2 inhibitor) lowers blood glucose by increasing urinary glucose excretion from the kidneys. Linagliptin (DPP-4 inhibitor) increases incretin levels, enhancing insulin release and reducing glucagon secretion in a glucose-dependent manner.

Oral tablet. Take exactly as prescribed, usually once daily, with or without food (preferably at the same time each day). Swallow whole with water; maintain adequate hydration and follow diet/exercise advice.

Increased urination, urinary tract infection, genital fungal infection, thirst, dizziness, headache, nasopharyngitis, hypoglycaemia (especially with insulin/sulfonylureas)

For type 2 diabetes only; not for type 1 diabetes or diabetic ketoacidosis. Risk of dehydration/low blood pressure—drink fluids and use caution in elderly/diuretics. SGLT2 inhibitors may rarely cause ketoacidosis (seek care for nausea, vomiting, abdominal pain, breathlessness), urosepsis/pyelonephritis, and genital infections (including rare Fournier’s gangrene). Monitor kidney function; empagliflozin effectiveness reduces with severe renal impairment and may be contraindicated in advanced CKD—follow prescriber advice. Stop temporarily during major surgery/acute serious illness or prolonged fasting as advised. Risk of pancreatitis is rare with DPP-4 inhibitors; stop if severe abdominal pain occurs.

Insulin and sulfonylureas (increased hypoglycaemia risk), diuretics (increased dehydration/hypotension risk), lithium (may reduce levels with SGLT2 inhibitors), rifampicin (may reduce linagliptin exposure), strong P-gp/CYP3A4 inducers (e.g., carbamazepine, phenytoin, phenobarbital, rifampin) may decrease linagliptin effect; monitor glucose and adjust therapy as needed.

Store at room temperature (below 25°C), in a dry place, protected from moisture and light. Keep out of reach of children.

Glyxambi 10/5 Tablet, Jardiance Duo 10/5 Tablet, EmpaLin 10/5 Tablet, Empagliflozin 10 mg + Linagliptin 5 mg tablets (various brands)